ACP-5862 suppresses esophageal squamous cell carcinoma growth through inducing apoptosis via activation of endoplasmic reticulum stress and ROS production.

Esophageal squamous cell carcinoma (ESCC) is a common type of human oral malignancy with poor survival. Presently, it is necessary to find new and effective drugs for clinical therapy. This study aimed to identify the potential anti-tumor effects of ACP-5862, a major metabolite of acalabrutinib, on human ESCC progression, and to reveal the underlying mechanisms.

Research on the drag reduction property of puffer (Takifugu flavidus) spinal nonsmooth structure surface.

Puffers show good drag reduction performance during migration. It is worth noting that spines which are different from ordinary fish scales are densely distributed on the puffer skin. Here, the special morphological structure of puffer spines was observed using microscopy techniques, accurate contour models were established based on image processing techniques and curve fitting, then feature sizes were obtained.

Evaluation of microRNA expression profiling in highly metastatic laryngocarcinoma cells.

Background: Until now, little is known about the role of miRNAs in the invasion and metastasis of Laryngeal squamous cell carcinoma (LSCC).

Objectives: This study aimed to explore the relationship between microRNA and the invasion and metastasis of LSCC.

Material And Methods: The highly metastatic laryngocarcinoma cells were obtained from the established animal model with spontaneous lymph node metastasis of LSCC in our previous study.

Auditory characteristics of noise-exposed memberscrossing age-related groups.

Objective: To report audiological characteristics in a group of noise-exposed crew members on board ships.

Methods And Materials: Clinical and audiological measurements including pure-tone thresholds, acoustic immittance results and tinnitus questionnaires were collected from both the ship crew members (study subjects) and their land based colleagues (controls).

Results: 1) Noise exposed crew members showed not only high frequency, but also low frequency hearing loss; 2) Hearing impairment increased with age, with 65.

Clinical observation on hearing conditions of centenarians in northern district of China.

Conclusion: The hearing conditions of the centenarians were quite poor as regards hearing thresholds and speech detection ability.

Objective: To investigate hearing conditions of centenarians.

Methods: A total of 54 centenarians in Rizhao and Linyi Districts in Shandong Province were investigated to assess hearing conditions of centenerians comprehensively by questionnaire investigation, pure-tone audiometry, acoustic immitance, intelligence evaluation, and speech detection scores.