Correction: FragGen: towards 3D geometry reliable fragment-based molecular generation.

[This corrects the article DOI: 10.1039/D4SC04620J.].

FragGen: towards 3D geometry reliable fragment-based molecular generation.

3D structure-based molecular generation is a successful application of generative AI in drug discovery. Most earlier models follow an atom-wise paradigm, generating molecules with good docking scores but poor molecular properties (like synthesizability and drugability). In contrast, fragment-wise generation offers a promising alternative by assembling chemically viable fragments.

Philtrum Reconstruction Using a Triangular-Frame Conchae Cartilage Graft in Secondary Cleft Lip Deformities.

Background: The philtrum represents an essential feature in the architecture of the upper lip and over all facial appearance. A missing philtral ridge and dimple after cleft lip repair is associated with aesthetic impairment. The authors therefore developed a novel strategy for philtrum reconstruction using a triangular-frame conchae cartilage.

Short term results of philtrum reconstruction with an orbicularis oris muscle flap in cleft patients.

Purpose: In the treatment of philtral ridge deficiency in cleft lip patients, optimal results are difficult to obtain due to visible scarring following surgery. The purpose of this article is to introduce a novel strategy for philtrum reconstruction along with an evaluation of postoperative outcomes of this technique.

Method: All patients with a deficiency of the philtrum underwent reconstruction of the philtral ridge and upper lip using an orbicularis oris muscle flap with a specific re-suturing technique in our study.