Coordinated Formation of IMPDH2 Cytoophidium in Mouse Oocytes and Granulosa Cells.

Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme catalyzing biosynthesis of guanine nucleotides, aggregates under certain circumstances into a type of non-membranous filamentous macrostructure termed "cytoophidium" or "rod and ring" in several types of cells. However, the biological significance and underlying mechanism of IMPDH assembling into cytoophidium remain elusive. In mouse ovaries, IMPDH is reported to be crucial for the maintenance of oocyte-follicle developmental synchrony by providing GTP substrate for granulosa cell natriuretic peptide C/natriuretic peptide receptor 2 (NPPC/NPR2) system to produce cGMP for sustaining oocyte meiotic arrest.

DPAGT1-Mediated Protein -Glycosylation Is Indispensable for Oocyte and Follicle Development in Mice.

Post-translational modification of proteins by -linked glycosylation is crucial for many life processes. However, the exact contribution of -glycosylation to mammalian female reproduction remains largely undefined. Here, DPAGT1, the enzyme that catalyzes the first step of protein -glycosylation, is identified to be indispensable for oocyte development in mice.

One-Pot Facile Fabrication of Bioavailable Iron Nanoparticles with Good Biocompatibility for Anemia Therapy.

BACKGROUND Iron deficiency anemia (IDA) has been a major public health problem all over the world. Developing new iron (Fe) fortificants with both high bioavailability and negligible food sensory changes for IDA is in urgent demand. MATERIAL AND METHODS The Fe nanoparticles were fabricated through a one-pot reduction process under the protection of bovine serum albumin (BSA).

synthesis of molybdenum carbide/N-doped carbon hybrids as an efficient hydrogen-evolution electrocatalyst.

The development of non-precious metal based electrocatalysts for the hydrogen evolution reaction (HER) has received more and more attention over recent years owing to energy and environmental issues, and Mo based materials have been explored as a promising candidate. In this work, molybdenum carbide/N-doped carbon hybrids (MoC@NC) were synthesized facilely one-step high-temperature pyrolysis by adjusting the mass ratio of urea and ammonium molybdate. The MoC@NC consisted of ultrasmall nanoparticles encapsulated by N-doped carbon, which had high specific surface area.