The soil-air exchange of OCPs and PCBs in the Tibetan Plateau: Emphasis on episodic transport of unintentionally produced PCBs.

Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in paired ambient and surface air fugacity samples were measured in the Tibetan Plateau (TP) from 2019 to 2022. The air concentrations of previously intentionally produced chemicals like dichlorodiphenyltrichloroethane (DDT) and hexachlorocyclohexane (HCH) declined. Their soil-air exchange direction ranged from equilibrium to volatilization, suggesting that the TP is acting as a secondary source of most OCPs and PCBs with the pollution alleviation.

Occurrence and distribution of organophosphate flame retardants in the typical soil profiles of the Tibetan Plateau, China.

The urbanization and development of Tibetan Plateau (TP) probably results in a significant contamination of organic pollutants, such as organophosphate flame retardants (OPFRs). However, there is a lack of monitoring and evaluation of their occurrence and risks in the soil of TP. We investigated the concentrations, vertical distributions, potential sources, and ecological risks of OPFRs in soil profiles from four regions of TP, China.

Status and risks of selenium deficiency in a traditional selenium-deficient area in Northeast China.

In agricultural lands with selenium (Se) deficiency, bioavailability of Se in plants is low. Residents from large-scale agricultural production areas with Se deficiency often suffer from endemic diseases because of consumption of agricultural products lacking in Se. One such area in Northeast China where Keshan disease and Kashin-Beck disease originated, was selected for investigating the geochemistry, influencing factors, and risks of Se in the agroecosystems.

LncRNA SNHG5 regulates SOX4 expression through competitive binding to miR-489-3p in acute myeloid leukemia.

Objectives: Currently, lncRNA plays an important role in the occurrence and development of acute myeloid leukemia (AML), including SNHG5. However, the role and mechanism of SNHG5 in AML remains unclear. In this study, we explored the regulatory mechanism of SNHG5 in the development of AML.

Levels, sources, isotope signatures, and health risks of mercury in street dust across China.

Spatial distribution and isotope signature of mercury (Hg) in street dusts across China were investigated by collecting dust samples from 14 cities and reviewing previously published data from an additional 46 cities. Potential sources of street dust and the associated health risks to humans were also assessed. The total Hg (THg) concentrations in street dust ranged from 0.

Polyphyllin I induces apoptosis and autophagy via modulating JNK and mTOR pathways in human acute myeloid leukemia cells.

Polyphyllin I (PPI), a bioactive component extracted from Paris polyphylla, was reported to have potent anticancer activities in previous studies. However, there were few reports on the effects and underlying mechanism of PPI in human acute myeloid leukemia cells. The present study demonstrated that PPI had an inhibitory effect through inducing apoptosis and autophagy in THP-1 and NB4 cells.