Publications by authors named "Chenmeng Ding"
Article Synopsis
- Pseudorabies virus (PRV) can create lifelong infections in nerve cells and blood lymphocytes, avoiding the immune system and potentially causing fetal death.
- The virus evades immune responses by downregulating swine leukocyte antigen class I (SLA I) molecules, but the specific mechanisms behind this suppression are poorly understood.
- Research shows that PRV proteins pUL44 and pUS6 significantly decrease SLA I expression, with pUS6 also affecting transport proteins that help present antigens, highlighting how PRV can hinder immune detection.
Vaccines (Basel)
September 2022
Article Synopsis
- Pseudorabies virus (PRV) variants have been affecting immunized herds in China since 2011, showing that existing vaccines are not fully effective against these new strains.
- A new strain, PRV ΔgE/TK/US3, was developed by deleting the US3 gene from an earlier modified virus, PRV ΔgE/TK, and it exhibited similar growth characteristics.
- Tests on mice showed that PRV ΔgE/TK/US3 was safe and induced a strong immune response, making it a potential new vaccine candidate to combat the ongoing pseudorabies epidemic in China.
