Ground-state flavin-dependent enzymes catalyzed enantioselective radical trifluoromethylation.

The introduction of fluoroalkyl groups into pharmaceutical compounds has the potential to enhance their therapeutic properties. Nevertheless, the synthesis of enantiomerically pure C(sp³)-CF₃ compounds poses a significant challenge. Biocatalysis offers precise stereochemical control, however, the scarcity of fluorine-containing natural products makes it difficult to find enzymes capable of incorporating fluoroalkyl groups.

A new thermostable Cu(II) coordination polymer: photocatalytic activity and application values on diabetes.

A Cu(II) coordination polymer with the composition of [Cu(L)(4,4'-bipy)]·2 n(ClO) (, HL = 4-methyl-L-phenylalanine and 4,4'-bipy is 4,4'-bipyridine), was successfully obtained by the reaction of the mixed ligand of HL and 4,4'-bipy with Cu(ClO) · 6HO under solvothermal condition. The as-synthesized compound not only has high thermal stability until 275°C but also excellent photocatalytic activity for the methyl blue solution degradation under the irradiation of ultraviolet light. Furthermore, the compound's treatment activity on the diabetes was determined and its relevant mechanism was also studied.