Publications by authors named "Chenlu Jian"
Article Synopsis
- The study investigates the role of C-X-C motif chemokine receptor 2 (CXCR2) in the development of chronic post-surgical pain (CPSP) and its underlying mechanisms, emphasizing its potential as a chemotactic factor.
- Using a rat model and primary microglia cells, the researchers explored the effects of CXCR2 inhibition and its interactions with related signaling pathways, specifically the JAK/STAT3 pathway and EPAC1.
- Findings suggest that high levels of CXCR2 activate the JAK1/STAT3 signaling pathway and enhance EPAC1 activation in microglia, leading to worsened CPSP symptoms.
