Personality traits as mediators in the association between rs12415800 polymorphism and depressive symptoms among Chinese college students.

Background: Previous research has linked polymorphisms in the gene to depressive symptoms, particularly in Chinese individuals. However, it is not clear how personality traits may contribute to this association.

Methods: To explore the potential mediating effect of personality traits, we utilized a mediation model to examine the relationship between the rs12415800 polymorphism and depressive symptoms in 787 Chinese college students.

The host genetics affects gut microbiome diversity in Chinese depressed patients.

The gut microbiome and host genetics are both associated with major depressive disorder (MDD); however, the molecular mechanisms among the associations are poorly understood, especially in the Asian, Chinese group. Our study applied linear discriminant analysis (LDA) effect size (LEfSe) and genome-wide association analysis in the cohort with both gut sequencing data and genomics data. We reported the different gut microbiota characteristics between MDD and control groups in the Chinese group and further constructed the association between host genetics and the gut microbiome.