Scalable imaging-free spatial genomics through computational reconstruction.

Tissue organization arises from the coordinated molecular programs of cells. Spatial genomics maps cells and their molecular programs within the spatial context of tissues. However, current methods measure spatial information through imaging or direct registration, which often require specialized equipment and are limited in scale.

Surface molecularly imprinted polymers with synthetic dummy template for simultaneously selective recognition of nine phthalate esters.

Dummy template molecularly imprinted polymers (DMIPs) on silica gel particles for simultaneously selective recognition of nine phthalate esters have been prepared. A novel dummy template molecule with similar structural skeleton to the phthalate ester, diethyl N,N'-phthaloyl-bis(11-aminoundecanoate), has been designed and synthesized. The DMIP films were grafted on the surface of silica gel particles by a sol-gel process with 3-aminopropyltriethoxysilane (APTES) and tetramethoxysilane (TEOS) as functional monomer and cross-linker, respectively, and the obtained sorbents have been characterized by FTIR with diffuse reflectance accessory.