Publications by authors named "Chenjing Duan"
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced stage, metabolic dysfunction-associated steatohepatitis (MASH), are increasingly recognized as a global health issue. This study examines the role of small RNAs in the spleen of MASH using a non-human primate model. We performed high-throughput small RNA sequencing on spleen tissues from MASH-primates, revealing significant alterations in the expression of small non-coding RNAs, especially miRNAs.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to explore how a high-fat diet (HFD) affects a specific gut bacterium, Roseburia intestinalis, and butyric acid levels, as well as their implications for ovarian function and gene regulation in female mice.
- - Mice fed an HFD for 36 weeks experienced increased body weight, reduced levels of Roseburia intestinalis and butyric acid, decreased intestinal goblet cells, and signs of inflammation, along with impaired development of ovarian follicles and altered epigenetic markers.
- - The findings suggest that a long-term high-fat diet can harm female reproductive health by disrupting gut bacteria and inflammation, which negatively influences both ovarian function and epigenetic processes.