Simultaneous monitoring of creatinine and urea in diversified clinical samples based on SERS-active PDMS-flower-like ZIF-67@Ag nanoparticles.

The sensitive, efficient, and simultaneous assay of creatinine and urea in different body fluid is crucial for the daily detection and treatment of chronic kidney disease. Here, we exploited a versatile composite surface enhanced Raman scattering (SERS) substrate of polydimethylsiloxane (PDMS)-flower-like ZIF-67@Ag nanoparticles (NPs) based on simple in-situ growth and ion sputtering strategies. The plasmonic Ag NPs assembled on the three-dimensional anisotropic ZIF-67 matrix, facilitating numerous resonant electromagnetic "hotspots".

Neutrophil-like cell membrane-coated metal-organic frameworks for siRNA delivery targeting NOX4 to alleviate oxidative stress in acute ischemic injury.

Although reperfusion is the most effective treatment for acute ischemic stroke, it often results in serious secondary ischemia/reperfusion (I/R) injury due to oxidative stress. This oxidative stress primarily results from the overproduction of reactive oxygen species (ROS) during reperfusion which, in turn, is largely induced by high expression of NADPH oxidase 4 (NOX4). Inhibiting NOX4 gene expression has therefore been proposed as a direct approach to reduce ROS production and promote angiogenesis.

Long Non-Coding RNAs as Diagnostic Biomarkers for Ischemic Stroke: A Systematic Review and Meta-Analysis.

Ischemic stroke is a serious cerebrovascular disease, highlighting the urgent need for reliable biomarkers for early diagnosis. Recent reports suggest that long non-coding RNAs (lncRNAs) can be potential biomarkers for ischemic stroke. Therefore, our study seeks to investigate the potential diagnostic value of lncRNAs for ischemic stroke by analyzing existing research.

High-throughput and high-sensitive direct detection for pathogenic bacteria of urinary tract infections mediated by block-based design of flexible non-metallic composite SERS substrate.

It remains a huge challenge to realize a high-throughput direct detection for pathogenic bacteria with high-sensitivity in practice. Here, we develop a typical two-dimensional (2D) composite semiconductor of BP@MoS with special synergistic chemical enhancement-mediated surface-enhanced Raman scattering (SERS) activity. The relative proportion of MoS and BP was rationally adjusted in the hydrothermal reaction to screen a composite sample with high charge transfer efficiency.

Ultrasensitive SERS-based detection of prostate cancer exosome using CuO-CuO@Ag composite nanowires.

Exosome is a recently emerging cancer-associated biomarker for early diagnostic and prognostic owing to their noninvasive, intrinsic stability, and representativeness of primitive cell state. However, the development of convenient and quantitative methods for exosome analysis remains technically challenging. Here, we proposed a cost-effective assay for the direct capture and rapid monitoring of exosomes utilizing the multifunctional surface enhanced Raman scattering (SERS) substrate, which consisted of CuO-CuO nanowires prepared by a simple thermo-oxidative growth method and subsequently sputtered with Ag NPs.

Effectiveness and safety of finerenone in diabetic kidney disease patients: a real-world observational study from China.

Aims: Finerenone has been approved for treating diabetic kidney disease (DKD) with reducing cardiorenal risk. Real-world data on finerenone treatment for the management of DKD are presently lacking. This study aimed to investigate the effect of finerenone on the renal parameters of the Chinese DKD population in the real-world medical setting for the first time, especially in combination with renin-angiotensin system inhibitors (RASi) and sodium-glucose cotransporter 2 inhibitors (SGLT2i).

A WO/MoO hybrid oxide based SERS FET and investigation on its tunable SERS performance.

Active control of the surface-enhanced Raman scattering (SERS) enhancement shows great potential for realizing smart detection of different molecules. However, conventional methods usually involve time-consuming structural design or a sophisticated fabrication process. Herein, we reported an electrically tunable field effect transistor (FET) comprising a WO/MoO hybrid as the SERS active layer.

Synergistic photoinduced charge transfer resonance from porous ZIF-67 decorated violet phosphorus array for SERS immunoassay of SARS-CoV-2 spike protein.

As a rapid, highly sensitive, and user-friendly technique, surface-enhanced Raman scattering (SERS) has an extraordinary appeal to home self-test of COVID-19 during the post pandemic era. However, most of the existing SERS substrates have been still criticized in stability, repeatability, and sample enrichment. To address these obstacles, a novel non-metallic SERS substrate with porous surfaces and array geometry was developed by in-situ growing ZIF-67 particles on two-dimensional violet phosphorus (VP) matrix.

Porous carbon film/WO nanosheets based SERS substrate combined with deep learning technique for molecule detection.

The Surface-enhanced Raman scattering (SERS) is an attractive optical detecting method with high sensitivity and detectivity, however challenges on large-area signal uniformity and complex spectra analysis methods always retards its wide application. Herein, a highly sensitive and uniform SERS detection strategy supported by porous carbon film/WO nanosheets (PorC/WO) based noble-metal-free SERS substrate and deep learning algorithm are reported. Experimentally, the PorC/WO substrate was prepared by high-temperature annealing the PorC/WO films under the argon atmosphere.

Biomimetic SERS substrate with silicon-mediated internal standard: Improved sensing of environmental pollutants and nutrients.

Biomimetic materials with fascinating natural micro-nano surface structures offer a good choice for the simple fabrication of surface-enhanced Raman scattering (SERS) substrate. This study presented a novel sodium carboxymethylcellulose (NaCMC)-Ag biomimetic substrate which was fabricated through the reverse replication of micro-nano structures from cantaloupe peel. Particularly, silicon nanoparticles (Si NPs) were doped into this flexible biomimetic substrate in its fabrication process.

Engineered muscle from micro-channeled PEG scaffold with magnetic FeO fixation towards accelerating esophageal muscle repair.

Engineered scaffolds are used for repairing damaged esophagus to allow the precise alignment and movement of smooth muscle for peristalsis. However, most of these scaffolds focus solely on inducing cell alignment through directional apparatus, often overlooking the promotion of muscle tissue formation and causing reduced esophageal muscle repair effectiveness. To address this issue, we first introduced aligned nano-ferroferric oxide (FeO) assemblies on a micropatterned poly(ethylene glycol) (PEG) hydrogel to form micro-/nano-stripes.

Therapeutic drug monitoring mediated by the cooperative chemical and electromagnetic effects of TiCT modified with Ag nanocubes.

It is pivotal for the credible utilization of surface-enhanced Raman scattering (SERS) technique in clinical drug monitoring to exploit versatile substrates with dependable quantitative detection and robust recognition abilities. Herein, a commendable electromagnetic-chemical dual-enhancement SERS substrate dependent on TiCT and Ag nanocubes (Ag NCs) was fabricated for the precise quantification of ritonavir and ibrutinib in serum. Specifically, it was revealed that numerous electromagnetic "hotspots" emerged nearby the extremely tiny nanogaps among the intimately clustered Ag NCs, which also acted as optimal channels to facilitate effective photo-induced charge transfer (PICT) between the two-dimensional TiCT matrix and target molecules.

SERS-active immunoassay kit for SARS-CoV‑2 mediated by the cooperative chemical and electromagnetic effects of MXene modified with gold nanowires.

Surface-enhanced Raman scattering (SERS) technique with high sensitivity, reliable specificity, and rapid recognition ability exhibits attractive promise for the effective fast-monitoring of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, a novel SERS-active immunoassay kit for SARS-CoV-2 nucleocapsid (N) protein was prepared by in-situ growing gold (Au) nanowire forests (NFs) onto TiCT, which was then modified onto polymethyl methacrylate (PMMA) matrix and encapsulated into kit. It was noted that the Au nanowires with fibrous structures which vertically anchored on TiCT served as perfect channels to promote photo-induced charge transfer.

Insights into the Semiconductor SERS Activity: The Impact of the Defect-Induced Energy Band Offset and Electron Lifetime Change.

The significant boost in surface-enhanced Raman scattering (SERS) by the chemical enhancement of semiconducting oxides is a pivotal finding. It offers a prospective path toward high uniformity and low-cost SERS substrates. However, a detailed understanding of factors that influence the charge transfer process is still insufficient.

A hybrid SERS sensing platform constructed by porous carbon/Ag nanoparticles for efficient imatinib detection in bio-environment.

Surface enhanced Raman scattering (SERS) is a rapid and non-destructive spectral detection technique, and has been widely implemented on trace-level molecule detection. In this work, a hybrid SERS substrate constructed by porous carbon film and silver nanoparticles (PCs/Ag NPs) was developed and then used for imatinib (IMT) detection in bio-environment. The PCs/Ag NPs was prepared by direct carbonizing the gelatin-AgNO film in the air atmosphere, and an enhancement factor (EF) of 10 was achieved with R6G as the Raman reporter.

Ag NC and Ag NP/PorC Film-Based Surface-Enhanced Raman Spectroscopy-Type Immunoassay for Ultrasensitive Prostate-Specific Antigen Detection.

Surface-enhanced Raman scattering (SERS) is a spectral detection technology with high sensitivity and detectivity and can be used to detect the fingerprint information of the molecules with ultralow concentration. Herein, a kind of immunostructure constructed by Ag nanoparticle/porous carbon (Ag NP/PorC) films as the immunosubstrate and Ag NCs as the immunoprobes was presented for ultralow level prostate-specific antigen (PSA) detection. Experimentally, the Ag NP/PorC film was first prepared with a facile method by carbonizing the gelatin-AgNO film in air, and Ag NCs were synthesized by the hydrothermal method.

Recyclable detection of gefitinib in clinical sample mediated by multifunctional Ag-anchored g-CN/MoS composite substrate.

Surface-enhanced Raman scattering (SERS) technology enables to satisfy the increasing demand of clinical drug monitoring due to the superiority of fingerprint recognition, real-time response, and nondestructive collection. Here, a novel graphitic carbon nitride (g-CN)/ molybdenum disulfide (MoS)/Ag composite substrate with a 3D surface structure was successfully developed for the recyclable detection of gefitinib in serum. Attributed to the uniform and dense "hotspots" on the shrubby active surfaces in conjunction with the potential synergistic chemical enhancement of g-CN/MoS heterosystem, a remarkable SERS sensitivity with an attractive enhancement factor value of 3.

Nonmetallic SERS-based biosensor for ultrasensitive and reproducible immunoassay of ferritin mediated by magnetic molybdenum disulfide nanoflowers and black phosphorus nanosheets.

To improve the curability of cancer patients, it is essential to propose an early diagnosis technology with ultra-high sensitivity and reliable biocompatibility. Herein, a sophisticated nonmetallic SERS-based immunosensor, comprised by a MoS @FeO nanoflower-based immunoprobe with magnetism and a black phosphorus (BP) nanosheet-based immunosubstrate, was proposed for the specific in-situ monitoring of ferritin (FER). The sandwich immunosensor was endowed with an excellent SERS performance mainly ascribed to a synergistic chemical enhancement as well as an additional electrostatic adsorption effect, achieving a limit of detection down to 7.

Ultraviolet-ozone concomitantly induced MoS/MoO heterostructures with improved SERS performance.

Surface-enhanced Raman scattering (SERS) is a non-destructive spectral analysis technique. It has the virtues of high detectivity and sensitivity, which have been extensively studied for low-trace molecule detection. In the choices of SERS substrate materials, low-cost and abundant reserved transition metal oxide/chalcogenide materials have been regarded as promising substitutes for noble metals; however, their inferior SERS enhancement severely limits their practical application.

Quantitative detection of purine from food products with different water activities using needle-based surface-enhanced Raman scattering sensors.

Typically, for accurate quantitative tests of molecules, considering the actual solute concentration in the environment with different water activities (Aws) is essential. Accordingly, for effective detection of food substances, this paper proposes a non-destructive pluggable sensor to capture and monitor four free purines based on surface-enhanced Raman scattering characteristics such as sensitivity, uniformity, repeatability, and stability. In particular, we investigate the impact of Aw on the evaluation of purine detection and its deviation corrections.

A non-metallic SERS-based immunoassay founded by light-harvesting effect and strengthened chemical enhancement.

Owing to its promising biocompatibility and reliable sensitivity, semiconductor-guided surface-enhanced Raman scattering (SERS) technology has aroused widespread concern in clinical immunoassays. Herein, the well-improved light capture capability of MoS with a novel three-dimensional (3D) flower-like morphology was combined with the synergistic chemical enhancement from a MoS@red phosphorus (RP) hybrid system, facilitating an attractive non-metallic SERS-based detection of ferritin in serum. Owing to the remarkable enhancement factors of both the immunoprobe and immunosubstrate, which were comparable to noble metal, an extremely low limit detection of 11.

SERS-based recyclable immunoassay mediated by 1T-2H mixed-phase magnetic molybdenum disulfide probe and 2D graphitic carbon nitride substrate.

Recently, non-metallic SERS-based immunoassay has attracted much attention due to its attractive chemical enhancement (CM), chemical stability, and biocompatibility. Herein, metallic (1T)-semiconductor (2H) mixed-phase magnetic molybdenum disulfide (MoS) was rationally developed and combined with two-dimensional (2D) graphitic carbon nitride (g-CN) nanosheets to realize a SERS-based recyclable immunoassay of CA125. The FeO core promoted the reliable stacking of MoS nanoflakes into a flower-like shape with fully-exposed active surface.

Activated cascade effect for dual-mode ratiometric and smartphone-assisted visual detection of curcumin and F based on nitrogen-doped carbon dots.

The growing persistence of harmful ion or drug molecular residues has always been considered as a matter of concern due to its importance in biological and environmental processes, which requires taking measures to maintain environmental health sustainably and effectively. Inspired by the multi-system and visual quantitative detection of nitrogen-doped carbon dots (N-CDs), we develop a novel cascade nano-system based on dual emission carbon dots for on-site visual quantitative detection of curcumin and fluoride ion (F). Herein, tris (hydroxymethyl) aminomethane (Tris) and m-dihydroxybenzene (m-DHB) are elected as reaction precursors to synthesize dual-emission N-CDs by a one-step hydrothermal method.