Celastrol ameliorates fibrosis in Western diet/tetrachloromethane-induced nonalcoholic steatohepatitis by suppressing Notch/osteopontin signaling.

Background: Celastrol was recently identified as a potential treatment for obesity and hepatic steatosis. However, whether Celastrol effectively suppresses the nonalcoholic fatty liver disease (NAFLD) stage remains unknown. This study aimed to evaluate the role of Celastrol in the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) and fibrosis.

Deployment of Industry 4.0 technologies to achieve a circular economy in agri-food supply chains: A thorough analysis of enablers.

With the global population projected to reach 9.7 billion by 2050, pressure on global natural resources will increase by 50-90%, exceeding planetary boundaries. Industry 4.

Body posture can modulate liver stiffness measured by transient elastography: a prospective observational study.

Background: Non-invasive measurement of liver stiffness (LS), traditionally performed in the supine position, has been established to assess liver fibrosis. However, fibrosis degree is not the sole determinant of LS, necessitating the identification of relevant confounders. One often-overlooked factor is body posture, and it remains unclear whether normal daily postures interfere with LS irrespective of fibrosis.

A Population-Based and Clinical Cohort Validation of the Novel Consensus Definition of Metabolic Hyperferritinemia.

Context: There is limited data on the clinical significance of metabolic hyperferritinemia (MHF) based on the most recent consensus.

Objective: We aimed to validate the clinical outcomes of MHF in the general population and patients with biopsy-proven metabolic dysfunction-associated fatty liver disease (MAFLD).

Methods: The NHANES database and PERSONS cohort were included.

PGC1α deficiency reverses cholestasis-induced liver injury via attenuating hepatic inflammation and promoting bile duct remodeling.

Objectives: Cholestatic liver diseases are characterized by hepatocellular damage, cholangiocyte proliferation, and progressive fibrosis. Bile duct ligation (BDL) is widely used to resemble liver injuries induced by cholestasis. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC1α) was reported to play a critical role in multiple biological responses.

Generation and transmission of multiband and multi-gigabit 60-GHz MMW signals in an RoF system with frequency quintupling technique.

We propose and experimentally demonstrate a cost-effective radio-over-fiber (RoF) system to simultaneously generate and transmit multiband and multi-gigabit 60-GHz millimeter wave (MMW) signals using frequency quintupling technique. Multiband signals at 56-GHz and 60-GHz are realized with two cascaded single-drive Mach-Zehnder modulators (MZMs), where phase control is not required. Furthermore, only low-frequency (≤12GHz) optical and electrical devices are used in the central station (CS), which enable a cost-effective system.