Revealing Differential RNA Editing Specificity of Human ADAR1 and ADAR2 in .

Adenosine-to-inosine (A-to-I) RNA editing is an important post-transcriptional modification mediated by the adenosine deaminases acting on RNA (ADAR) family of enzymes, expanding the transcriptome by altering selected nucleotides A to I in RNA molecules. Recently, A-to-I editing has been explored for correcting disease-causing mutations in RNA using therapeutic guide oligonucleotides to direct ADAR editing at specific sites. Humans have two active ADARs whose preferences and specificities are not well understood.

Patient Perceptions of Microbiome-Based Therapies as Novel Treatments for Mood Disorders: A Mixed Methods Study: Perceptions des patients sur les thérapies basées sur le microbiome pour les troubles de l'humeur : une étude à méthodes mixtes.

Objective: Medications are critical for treating major depressive disorder (MDD) and bipolar disorder (BD). Unfortunately, 30% to 40% of individuals do not respond well to current pharmacotherapy. Given the compelling growing body of research on the gut-brain axis, this study aims to assess patient perspectives regarding microbiome-based therapies (MBT) such as probiotics, prebiotics, dietary changes, or fecal microbiota transplantation (FMT) in the management of MDD and BD.

Diverse performances for Pb(II) adsorption by in situ formed Fe(III) oxyhydroxide derived from ferrate(VI) reduction and ferrous oxidation.

Two in situ formed Fe(III) oxyhydroxides (FeO) originated from ferrate reduction (designated FeO-Fe) and ferrous oxidation by HO (designated FeO-Fe) were compared in the aspects of morphology, hydrolyzed species, surface binding mechanism of lead. The theoretical maximum adsorption capacity calculated from the Langmuir model toward Pb(II) was 929.54 and 810.

Highly sensitive and specific detection of silver ions using a dual-color fluorescence co-localization strategy.

Ag ions are widely used in various fields of human life due to their unique properties and they threaten the environment and human health. The traditional methods for Ag detection commonly suffer from disadvantages including limited sensitivity, expensive equipment and complicated operating steps. Herein, we developed a highly specific dual-color fluorescence co-localization (DFC) strategy based on the C-Ag-C structure for Ag detection.

Enhanced Adsorption of Bromoform onto Microplastic Polyethylene Terephthalate Exposed to Ozonation and Chlorination.

This paper selected microplastic polyethylene terephthalate (PET), commonly found in water/wastewater plant effluent, to investigate the changes of PET oxidized under ozonation (designated as ozonized PET), followed by sodium hypochlorite oxidation (designated as ozonized-chlorinated PET) and studied their influence on the adsorption of the disinfection by-product bromoform (TBM). Fragmentation and cracks appeared on the oxidized PET surface. As the oxidation degree increased, the contact angle decreased from 137° to 128.

Construction of RNA nanocages by re-engineering the packaging RNA of Phi29 bacteriophage.

RNA nanotechnology promises rational design of RNA nanostructures with wide array of structural diversities and functionalities. Such nanostructures could be used in applications such as small interfering RNA delivery and organization of in vivo chemical reactions. Though having impressive development in recent years, RNA nanotechnology is still quite limited and its programmability and complexity could not rival the degree of its closely related cousin: DNA nanotechnology.

Vernier assembly: controlling DNA polymerization via length mismatching.

Inspired by the principle of the Vernier scale, length mismatching was used to control the lengths of supramolecular DNA polymers.

Approaching the limit: can one DNA strand assemble into defined nanostructures?

This article reports a simple, symmetrical DNA building block (motif): a bulged DNA duplex consisting of two short, identical strands. Multiple copies of the same motif can interact with each other through T junctions. The resulting superstructures include predesigned 1D and 2D arrays that have been visualized by atomic force microscopy (AFM).

RNA-DNA hybrid origami: folding of a long RNA single strand into complex nanostructures using short DNA helper strands.

Quick folding of a long RNA strand using short DNA staple strands (at a 1 : 1 ratio) into various pre-designed nanostructures in high yields has been demonstrated.

Reversibly switching the surface porosity of a DNA tetrahedron.

The ability to reversibly switch the surface porosity of nanocages would allow controllable matter transport in and out of the nanocages. This would be a desirable property for many technological applications, such as drug delivery. To achieve such capability, however, is challenging.

DNA polyhedra with T-linkage.

This paper reports a strategy for DNA self-assembly. Cross-over-based DNA nanomotifs are held together by T-junctions instead of commonly used sticky-end cohesion. We have demonstrated this strategy by assembling a DNA tetrahedron, an octahedron, and an icosahedron.

A synthetic method for transition-metal chalcogenide nanocrystals.

In this paper, we prepared a series of chalcogenide semiconductor nanocrystals in controllable shape and size via a facile wet route using metal nitrates and sulfur or selenium powder as precursors and octadecylamine (ODA) as solvent. The as-obtained chalcogenides included CdS, MnS, Ag(2)S, PbS, Cu(1.8)S, Bi(2)S(3), ZnS, Zn(x)Cd(1-x)S, as well as Ag(2)Se, Cu(2-x)Se, CdSe, MnSe.

General synthesis of I-III-VI2 ternary semiconductor nanocrystals.

Metastable orthorhombic phase of AgInS2 nanocrystals with various shapes, including particles, rods, and worms, have been obtained to demonstrate a facile and effective one-pot chemical route for the synthesis of high quality I-III-VI2 ternary semiconductor nanocrystals (AgInS2, CuInS2, AgInSe2) with controllable shape and size.