Integrated Identification and Immunotherapy Response Analysis of the Prognostic Signature Associated With m6A, Cuproptosis-Related, Ferroptosis-Related lncRNA in Endometrial Cancer.

Background: Endometrial cancer (EC) stands as the predominant gynecological malignancy impacting the female reproductive system on a global scale. N6-methyladenosine, cuproptosis- and ferroptosis-related biomarker is beneficial to the prognostic of tumor patients. Nevertheless, the correlation between m6A-modified lncRNAs and ferroptosis, copper-induced apoptosis in the initiation and progression of EC remains unexplored in existing literature.

Efficacy and Safety of Anti-HER2 Targeted Therapy for Metastatic HR-Positive and HER2-Positive Breast Cancer: A Bayesian Network Meta-Analysis.

Despite the development of HER2-targeted drugs, achieving favorable outcomes for patients with HR+/HER2+MBC remains challenging. This study utilized Bayesian Network Meta-analysis to compare the efficacy and safety of anti-HER2 combination regimens. The primary analysis focused on progression-free survival (PFS), while secondary analyses included objective response rate, overall survival (OS) and the incidence rate of grade 3/4 adverse events (AEs).

Electronic and magnetic properties of phosphorene tuned by Cl and metallic atom co-doping.

Using first-principles calculations based on density functional theory, we studied the electronic and magnetic properties of phosphorene co-doped with Cl and a metal atom (including Sc, Ti, V, Cr, Mn, Fe, Co, and Ni). It is found that Cl atom doping makes it much easier for metallic atoms to dope into phosphorene. Phosphorene co-doped with Cl and V, Cr, Mn, or Fe is magnetic, which is determined by the number of valence electrons.