Publications by authors named "Chenhe Lu"
Circular RNAs (circRNAs) exert diverse biological functions in different processes. However, the role of circRNAs during virus infection is mostly unknown. Herein, we explored the characteristics of host circRNAs using alphaherpesvirus pseudorabies virus (PRV) as a model.
View Article and Find Full Text PDFIntroduction: Variant pseudorabies virus (PRV) is a newly emerged zoonotic pathogen that can cause human blindness. PRV can take advantage of its large genome and multiple non-essential genes to construct recombinant attenuated vaccines carrying foreign genes. However, a major problem is that the foreign genes in recombinant PRV are only integrated into the genome for independent expression, rather than assembled on the surface of virion.
View Article and Find Full Text PDFArticle Synopsis
- - Deltacoronavirus, which primarily affects pigs and wild birds, was identified in bird samples from Qinghai Lake, China, in 2021, showing a 5.94% positivity rate in fecal samples.
- - A new strain, named A/black-headed gull/Qinghai/2021 (BHG-QH-2021), was found to be genetically related to strains from the UAE, China, and Poland, raising concerns about potential cross-species transmission to humans.
- - Interestingly, the receptors that BHG-QH-2021 binds to are more similar to those of the human coronavirus 229E, suggesting a possible avenue for enhanced infection risk in humans despite its primary infection being limited to
An aptamer based assay is presented for the determination of the antibiotics oxytetracycline (OTC) and kanamycin (KAN). Magnetic beads were applied for separation, and gold nanoparticles (AuNPs) for signal amplification. DNA aptamers against OTC and KAN were firstly designed.
View Article and Find Full Text PDFBiological thiols (biothiols), an important kind of functional biomolecules, such as cysteine (Cys) and glutathione (GSH), play vital roles in maintaining the stability of the intracellular environment. In past decades, studies have demonstrated that metabolic disorder of biothiols is related to many serious disease processes and will lead to extreme damage in human and numerous animals. We carried out a series of experiments to detect biothiols in biosamples, including bovine plasma and cell lysates of seven different cell lines based on a simple colorimetric method.
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