Publications by authors named "Chengzhi Lv"
Article Synopsis
- * A standardized system for collecting and categorizing this data has been developed, including specific recommendations for measurement techniques and equipment based on usage contexts.
- * A multi-center collaboration in China seeks to gather data on various skin conditions, linking it to disease information to better understand skin phenotype influences and improve treatment methods, while also working on non-invasive measurement technologies.
Article Synopsis
- Psoriasis, an autoimmune disease, shows variations influenced by season and geography, highlighting the importance of studying double-stranded DNA (dsDNA) levels in relation to climate.
- A study from 2016 to 2020 analyzed 10,110 psoriasis patients across different regions in China, focusing on how serum dsDNA levels differed by season and latitude.
- Results indicated higher serum dsDNA levels in Northern and medium-latitude regions, during winter compared to summer, and emphasized the impact of factors like UV exposure, humidity, and age on dsDNA concentrations.
Psoriasis is an immune-mediated, chronic, relapsing, inflammatory, systemic disease induced by individual-environmental interactions, and is often lifelong because of the difficulty of treatment. In recent years, a variety of targeted therapies, including biologics, have improved the lesions and quality of life of most psoriasis patients, but they still do not address the problem of relapse and may be associated with decreased efficacy or adverse events such as infections over time. Therefore, there is an urgent need for breakthroughs in psoriasis treatment and in relapse-delaying and non-pharmacologic strategies, and stem cell therapy for psoriasis has emerged.
View Article and Find Full Text PDFArticle Synopsis
- Freckles are a common skin condition that has a hereditary link, with previous research identifying many genetic risk factors through studies on other diseases.
- A new study conducted a Genome-Wide Association Study (GWAS) and meta-analysis on 4,813 Chinese individuals, revealing new genetic variants linked to freckles.
- The research identified 59 new single nucleotide polymorphisms (SNPs) and 13 novel genes that may increase susceptibility to freckles, contributing significantly to the understanding of their genetic basis.
Introduction: The treatment options for moderate to severe psoriasis (msPsO) in China have been greatly increased with the approvals of biologics. However, the unmet needs and treatment preferences of systemic treatments for msPsO in China remain unclarified.
Methods: Fifty dermatologists and 300 patients with msPsO (41% with severe psoriasis) were surveyed for effectiveness, safety, treatment convenience, and treatment preferences (using a choice-based conjoint questionnaire).
Article Synopsis
- Ixekizumab is a monoclonal antibody used to treat moderate-to-severe plaque psoriasis, showing positive results in terms of effectiveness and tolerance, but there's a lack of safety data specific to Chinese patients.
- A real-world observational study followed 663 patients in China for adverse events while they received ixekizumab treatment over 12 weeks, evaluating various safety parameters.
- The study found that about 33.8% of patients reported at least one adverse event related to the treatment, with injection site reactions, infections, and allergic reactions being the most common, and noted that female patients experienced a higher proportion of adverse events compared to males.
Introduction: Ixekizumab, a monoclonal antibody against interleukin-17A, demonstrated effectiveness in the treatment of psoriasis in a Chinese real-world study that was consistent with previous randomized controlled trials. Here, we report further analyses from this study to explore the effectiveness of ixekizumab for treating patients with psoriasis and the involvement of special body areas (scalp, nail, joint, palmoplantar, or genital areas).
Methods: A multicenter, prospective, observational, single-arm, post-marketing surveillance study was conducted in patients aged ≥ 18 years with moderate-to-severe plaque psoriasis and prescribed with ixekizumab in 26 Chinese hospitals.
Article Synopsis
- - Psoriasis is a chronic inflammatory disease affecting over 6 million people in China, and the study focused on the real-world use of ixekizumab, a treatment targeting interleukin-17A for moderate-to-severe plaque psoriasis.
- - In a study involving 666 patients, 42.7% reported at least one adverse event, mostly mild, with serious events being rare; the majority showed significant improvement in their psoriasis symptoms within 12 weeks.
- - By week 12, a large percentage of patients achieved notable reductions in psoriasis severity and improvements in quality of life, indicating that ixekizumab is both effective and well-tolerated in a clinical setting.
Secukinumab is effective in treating patients with moderate-to-severe plaque psoriasis. However, most studies assessing its effectiveness in routine clinical settings in China are mostly single-center studies with a limited sample size. The objective of this study was to assess secukinumab's efficacy, treatment patterns, and characteristics in patients with moderate-to-severe plaque psoriasis.
View Article and Find Full Text PDFBackground: Newer biologics, such as interleukin (IL)-17 inhibitors, make it possible to achieve complete skin clearance (CSC) in patients with moderate-to-severe psoriasis. However, the clinical meaningfulness and predictive factors of CSC in daily practice have not yet been fully investigated.
Objective: The study was conducted to, first, assess the impact of CSC on quality of life (QoL) improvements compared with treatment responses without clearance and, second, identify clinical parameters as predictors of CSC response in psoriasis patients treated with ixekizumab.
Background: Psoriasis is one of the most frequent inflammatory skin conditions and could be treated via tele-dermatology, provided that the current lack of reliable tools for objective severity assessments is overcome. Psoriasis Area and Severity Index (PASI) has a prominent level of subjectivity and is rarely used in real practice, although it is the most widely accepted metric for measuring psoriasis severity currently.
Objective: This study aimed to develop an image-artificial intelligence (AI)-based validated system for severity assessment with the explicit intention of facilitating long-term management of patients with psoriasis.
Background: Chronic, low-grade inflammation, also termed 'inflammaging', has been linked to the development of some aging-associated disorders. Recent studies suggest that inflammaging is attributable to aging-associated epidermal dysfunction. However, abnormality in which epidermal function contributes to inflammaging is not clear.
View Article and Find Full Text PDFObjective: Novel core-shell lipid-gelatin-epigallocatechin-3-gallate hybrid nanoparticles (LGE-N) were prepared to increase the stability and antitumor efficacy of epigallocatechin-3-gallate (EGCG).
Methods: The LGE-N was prepared by a single-step double-emulsion method, in which EGCG-gelatin nanoparticles were formed and stabilized in the inner phase by gelatinization. The cytotoxicity of EGCG solution (EGCG-S) and LGE-N were assessed by a standard 3-(4, 5-dimethylthiazol- 2-yl)-2, 5-diphenyltetrazolium bromide assay.
Background: Real-life studies evaluating the long-term efficacy of guselkumab in moderate-to-severe psoriasis in China are limited and not available.
Methods: In this real-life study, we retrospectively examined a total of 27 patients with moderate-to-severe psoriasis treated with guselkumab [100 mg, subcutaneous (s.c.
Objective: This study aimed to develop a risk of psoriatic arthritis (PsA) predictive model for plaque psoriasis patients based on the available features.
Methods: Patients with plaque psoriasis or PsA were recruited. The characteristics, skin lesions, and nail clinical manifestations of the patients have been collected.
Reductive Effect of Acitretin on Blood Glucose Levels in Chinese Patients With Psoriasis.
Front Med (Lausanne)
December 2021
Psoriasis is a skin condition associated with increased risks of developing metabolic diseases, such as diabetes and hyperlipidaemia. Retinoid drugs, including acitretin, are commonly used to treat psoriasis due to its low cost and tolerable side effects. This study aimed to explore the influence of acitretin on patients' metabolism levels, especially lipid and glucose.
View Article and Find Full Text PDFPurpose: Vaccination is one of the most important strategy to prevent infections and control epidemics, but it also raises concerns about safety in patients receiving treatments. This study aimed to investigate the rate and factors for unvaccination, as well as adverse reactions and deterioration of disease after SARS-CoV-2 vaccination in psoriatic patients.
Methods: A web-based questionnaire survey on SARS-CoV-2 vaccination, adverse reactions, and self-reported change of disease condition after vaccination in patients with psoriasis was conducted.
Isothiocyanates (ITCs) are well-known chemopreventive agents that have received significant interest across the nutrition and pharmaceutical industries owing to their anticancer properties, thus it is essential to increase the conversion of glucosinolate to ITCs by myrosinase to maximize their health benefits. In this paper, using broccoli seed meals as a raw material, we comparatively analyzed the outcomes of two extraction methods: (i) hydrolysis followed by extraction (HFE) and (ii) simultaneous hydrolysis and extraction (SHE) in terms of the ITC yield. The results revealed that the SHE method showed a relatively greater erucin production from broccoli seeds and greater antitumor and antioxidant activities.
View Article and Find Full Text PDFThe isothiocyanate sulforaphane (SF) is one of the most potent naturally occurring Phase 2 enzymes inducers derived from brassica vegetables like broccoli, cabbage, brussel sprouts, etc. Ingestion of broccoli releases SF via hydrolysis of glucoraphanin (GRP) by plant myrosinase and/or intestinal microbiota. However, both SF and plant myrosinase are thermal-labile, and the epithiospecifier protein (ESP) directs the hydrolysis of GRP toward formation of sulforaphane nitrile instead of SF.
View Article and Find Full Text PDFBackground: Topical agents are still the mainstay for the treatment of mild-to-moderate plaque psoriasis, in which fixed combinations play an important role. Tazarotene/betamethasone dipropionate (Taz/BD) cream is a novel fixed combination approved for treating plaque psoriasis in China, but its efficacy and safety have not been verified in a real-world environment.
Objectives: The primary objective was to investigate the efficacy and safety of Taz/BD cream in treating plaque psoriasis.
Purpose: The COVID-19 epidemic has caused difficulties in continuous treatment for patients with chronic diseases and resulted in nonadherence to treatment and adverse health outcomes. This study aimed to investigate the associations of nonadherence to treatment with patient-reported outcomes of psoriasis during the COVID-2019 epidemic.
Methods: A cross-sectional study among Chinese patients with psoriasis was conducted through a web-based questionnaire survey during 25 Feb 2020 and 6 Mar 2020.
Psoriasis is a chronic recurrent inflammatory disease involving many common mechanisms associated with obesity, such as systemic inflammation and vitamin D deficiency. This study aimed to examine the association of the serum concentration of 25-hydroxyvitamin D with psoriasis and the effect modification by obesity among the affected patients. A mixed cross-section study was conducted.
View Article and Find Full Text PDF