Evaluation of virulence of Aeromonas veronii strain GZ21-2 and development of a highly effective vaccine for grass carp with the potential for industrial application.

Bacterial septicemia represents a significant disease affecting cultured grass carp culture, with the primary etiological agent identified as the Gram-negative bacterium Aeromonas veronii. In response to an outbreak of septicemia in Guangzhou, we developed a formaldehyde-inactivated vaccine against an A. veronii strain designated AV-GZ21-2.

Case Report: Identification of a rare nonsense mutation in the gene by NGS in a diabetes mellitus patient.

This study aimed to investigate the clinical and molecular biology of a patient with a type of diabetes mellitus caused by a mutation in the (OMIM number: 614783) gene and explore its pathogenesis and related characteristics. The patient was interviewed about his medical history and subjected to relevant examinations. Blood DNA samples were collected from the patient and his family members (parents) for trio whole-exome sequencing.