biomechanical investigations of combined extra- and intracapsular stabilization in canines with cranial cruciate ligament deficiency.

Intracapsular reconstruction (ICR) has long been recommended as a treatment for cranial cruciate ligament deficiency (CCLD) in dogs, but it has fallen out of favor due to its inferior long-term functional outcomes. These outcomes may be attributed to the poor stiffness and strength of the graft in the early period before ligamentization is completed. Additional placement of extracapsular sutures to mechanically protect the graft during the ligamentization process may be a viable method to address this problem.

The Numerical Simulations and Experimental Study of an 8-Inch SiC Single Crystal with Reduced BPD Density.

The basal plane dislocation (BPD) density is one of the most important defects affecting the application of SiC wafers. In this study, numerical simulations and corresponding experiments were conducted to investigate the influence of cooling processes, seed-bonding methods, and graphite crucible materials on the BPD density in an 8-inch N-type 4H-SiC single crystal grown by the physical vapor transport (PVT) method. The results showed that the BPD density could be effectively reduced by increasing the cooling rate, optimizing the seed-bonding method, and adopting a graphite crucible with a similar coefficient of thermal expansion as the SiC single crystal.

Ex vivo biomechanical evaluation of extracapsular stabilization with quasi-isometric points in canine cranial cruciate ligament-deficient stifles.

Background: Cranial cruciate ligament (CCL) disease is one of the most common causes of lameness in dogs. The extracapsular stabilization (ECS) utilizing bone anchors and monofilament nylon leader was an alternative treatment for CCL-deficient (CCLD) dogs. However, the biomechanical response of the canine stifle to such a surgical repair strategy in conjunction with the use of recently reported quasi-isometric anchoring points remains unclear.

Liver Lipidomics Analysis Revealed the Novel Ameliorative Mechanisms of L-Carnitine on High-Fat Diet-Induced NAFLD Mice.

The beneficial effects of L-carnitine on non-alcoholic fatty liver disease (NAFLD) were revealed in previous reports. However, the underlying mechanisms remain unclear. In this study, we established a high fat diet (HFD)-induced NAFLD mice model and systematically explored the effects and mechanisms of dietary L-carnitine supplementation (0.

Lanthanide Single-molecule Magnets: Synthetic Strategy, Structures, Properties and Recent Advances.

Single-molecule magnets (SMMs) show wide potential applications in the field of ultrahigh-density storage materials, quantum computing, spintronics, and so on. Lanthanide (Ln) SMMs, as an important category of SMMs, open up a promising prospect due to their large magnetic moments and huge magnetic anisotropy. However, the construction of high performance for Ln SMMs remains an enormous challenge.

lipid-lowering formula alleviates fat and lipid accumulation by modulating gut microbiota and short-chain fatty acids in high-fat diet mice.

Obesity has caused serious health and economic problems in the world. is a high-value macrofungus with broad application potential in the food and bio-medicine industry. This current study aimed to estimate the role of lipid-lowering compound formula (CGLC) in regulating fat and lipid accumulation, gut microbiota balance, short-chain fatty acid (SCFA) contents, and expression levels of genes involved in fat and lipid metabolism in high-fat diet (HFD) mice.

Dietary supplementation of L-carnitine ameliorates metabolic syndrome independent of trimethylamine -oxide produced by gut microbes in high-fat diet-induced obese mice.

Metabolic syndrome (MS) is a collection of risk factors of serious metabolic diseases. L-Carnitine is an essential nutrient for human health, and the precursor of trimethylamine -oxide (TMAO). Previous studies have shown that the effect of L-carnitine on MS is controversial, and no studies have considered the role of gut microbiota in the regulation of MS by L-carnitine.

Three Gd-based magnetic refrigerant materials with high magnetic entropy: From di-nuclearity to hexa-nuclearity to octa-nuclearity.

Magnetocaloric effect (MCE) is one of the most promising features of molecular-based magnetic materials. We reported three Gd-based magnetic refrigerant materials, namely, Gd(L)(NO)(HO)‧CHCN‧HO (, HL = ()--[(1)-(2-hydroxy-3-methphenyl)methylidene]pyrazine-2-carbohydrazonic acid), {Gd(L)(CO)(CHOH)(HO)Cl}Cl‧4CHCN (), and Gd(L)(CO)(HO)‧2HO (3). Complex contains two Gd ions linked by two : : : : -L ligands, which are seven-coordinated in a capped trigonal prism, and complex possesses six Gd ions, contributing to a triangular prism configuration.

Interviewer Error Within the Face-to-Face Food Frequency Questionnaire in Large Multisite Epidemiologic Studies.

Interviewer error has long been recognized in face-to-face surveys, but little is known about interviewer error within face-to-face food frequency questionnaires, particularly in large multisite epidemiologic studies. Using dietary data from the China Multi-Ethnic Cohort (2018-2019), in which all field interviews were audio recorded, we identified a potentially error-prone sample by outlier detection and further examined the interviewer errors by reviewing these error-prone interviews. Among 174,012 questions for 5,025 error-prone interviews, 13,855 (7.

A Photosensitizer Discretely Loaded Nanoaggregate with Robust Photodynamic Effect for Local Treatment Triggers Systemic Antitumor Responses.

Photodynamic therapy (PDT), is a rising star for suppression of and metastatic tumors, yet it is impeded by low ROS production and off-target phototoxicity. Herein, an aggregation degree editing strategy, inspired by gene editing, was accomplished by the coordination of an aggregation degree editor, (MEOMA--OEGMA)--SS [POEGS; MEOMA = 2-(2-methoxyethoxy)ethyl methacrylate, OEGMA = oligo(ethylene glycol) methacrylate; SS = poly(styrene sulfonate)] and indocyanine green (ICG) to nontoxic Mg, forming an ICG discretely loaded nanoaggregate (ICG-DNA). Optimization of the ICG aggregation degree [POEGS/ICG (P/I) = 6.

Biosynthetic Pathway and the Potential Role of Melatonin at Different Abiotic Stressors and Developmental Stages in .

Melatonin, a bioactive compound and an important signaling molecule produced in plants and animals, is involved in many biological processes. However, its function and synthetic pathways in fungi are poorly understood. Here, the samples from , a highly valued edible fungus with functional food properties, were collected under different experimental conditions to quantify the levels of melatonin and its intermediates.

Bio-based visual optical pressure-responsive sensor.

A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer. The white aerogel is composed of consecutive ribbons, demonstrating chiral nematic structure. These ribbons are rearranged to be vertical to the force direction, leading to immediate appearance of the structural color when the 3D aerogel transforms to a 2D plane.

Identification of microRNA-like RNAs in Cordyceps guangdongensis and their expression profile under differential developmental stages.

Cordyceps guangdongensis is a well-known fungus with high nutritional and medicinal value. The metabolite profile of C. guangdongensis is similar to that of Ophiocordyceps sinensis.

Orchestration of lincRNA-p21 and miR-155 in Modulating the Adaptive Dynamics of HIF-1α.

Hypoxia-inducible factor-1 (HIF-1) is the key regulator of cellular adaptive response to hypoxia. Accumulating evidence shows that HIF-1 induces some non-coding RNAs (ncRNAs) including lncRNAs and miRNAs to modulate its own activity, enclosing several feedback loops. How the two classes of ncRNAs are orchestrated in the HIF-1-dependent adaptive response to hypoxia is poorly understood.

Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.

Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances. Herein, a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity was fabricated. Cellulose nanocrystals (CNCs) provided structural color with left-handed helicity.

Polysaccharide-based recoverable double-network hydrogel with high strength and self-healing properties.

Polysaccharide-based hydrogels (PSBHs) have received significant attention for numerous bio-applications due to their biocompatibility and non-immunogenic performance. However, the construction of PSBH with superior mechanical properties by a simple method is rarely adequately researched. This study focuses on the construction of a novel PSBH with superior mechanical and recoverable properties by integrating the synergistic and complementary interactions of covalent bond-associated oxidized sodium alginate (SA-CHO) gel and hydrogen bond-associated agarose (Aga) gel.

Humidity and Heat Dual Response Cellulose Nanocrystals/Poly(-Isopropylacrylamide) Composite Films with Cyclic Performance.

It has been widely reported that cellulose nanocrystals (CNCs) demonstrate a special structural color, which stems from chiral nematic domains. Herein, the humidity and heat dual response nanocomposite films with multilayered helical structure were prepared by self-assembling of CNCs and hydrazone groups modified poly(-isopropylacrylamide) (PNIPAM) copolymers. Furthermore, glutaraldehyde was involved to act as a chemical linker to improve cyclic stability by forming acylhydrazone bonds.

Coordination of miR-192 and miR-22 in p53-Mediated Cell Fate Decision.

p53-targeted microRNAs (miRNAs) markedly affect cellular response to DNA damage. These miRNAs may contribute to either cell cycle arrest or apoptosis induction. However, how these miRNAs coordinate to modulate the decision between cell survival and death remains less understood.

Fabrication of a Controlled in Situ Forming Polypeptide Hydrogel with a Good Biological Compatibility and Shapeable Property.

A hydrogel is required to have a good biocompatibility, permeability for nutrients, and an easy construction procedure for biomedical applications. In particular, in situ forming hydrogels (ISFHs) have triggered considerable interest in their facile preparation methods. Here, an enzyme-prompted ISF, biodegradable poly(l-lysine)-graft-4-hydroxyphenylacetic acid (PLL-g-HPA) hydrogel in the conditions of horseradish peroxidase (HRP) and hydrogen peroxide (HO) and with a good biocompatibility was developed.

Using spatio-temporal lagged association pattern to unravel the acute effect of air pollution on mortality.

Background: Acute mortality effects of air pollution have been recognized in plenty of environmental epidemiologic studies. However, existing studies usually assume a universal lag association across sites and seasons. Such a strategy ignores the heterogeneity of lag structures and may lead to bias in the estimation of effects.