Publications by authors named "Chengyong Xie"
Background: Tinnitus is an auditory phantom sensation in the absence of an acoustic stimulus, which affects nearly 15% of the population. Excessive noise exposure is one of the main causes of tinnitus. To now, the knowledge of the genetic determinants of susceptibility to tinnitus remains limited.
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- The study investigates genetic factors that influence the severity of COVID-19 in the Chinese population by comparing severe cases to milder ones.
- Researchers conducted a genome-wide association study and identified two specific genetic loci on chromosomes 11q23.3 and 11q14.2 linked to COVID-19 severity.
- Findings suggest potential genetic markers for understanding COVID-19's pathogenesis and could lead to improved clinical treatments for the disease.
Noise-induced hearing loss (NIHL) seriously affects the life quality of humans and causes huge economic losses to society. To identify novel genetic loci involved in NIHL, we conducted a genome-wide association study (GWAS) for this symptom in Chinese populations. GWAS scan was performed in 89 NIHL subjects (cases) and 209 subjects with normal hearing who have been exposed to a similar noise environment (controls), followed by a replication study consisting of 53 cases and 360 controls.
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