Publications by authors named "Chengying Zhao"

Article Synopsis
  • - Nobiletin (NBT) is a flavonoid found in citrus fruits, showing potential to prevent colon cancer in rodent studies, but its specific molecular targets were previously unknown.
  • - This study identifies HSC70 as a direct protein target of NBT in colon cancer cells, revealing that NBT binds to HSC70's ATP-binding site and inhibits its ATPase activity.
  • - The major metabolites of NBT produced in the colon also demonstrated similar inhibitory effects on HSC70, supporting the need for further research on the role of NBT and its metabolites in cancer prevention.
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Gelation is a critical property of citrus pectin. However, the roles played by neutral sugar side-chains on acid-induced pectin gelation remain poorly understood. Herein, galactan- or/and arabinan-eliminated pectins (P-G, P-A, and P-AG) were used to investigate the effects of side-chains on gelation.

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To facilitate the application of rhamnogalacturonan-I (RG-I)-enriched pectins (RGPs) as novel, healthy, and gelling food additives, this study compared the structural characteristics and gelling properties of RGPs extracted from citrus peel via four methods (alkali: AK, high-temperature/pressure: TP, citric acid: CA, and enzyme-assisted: EA extractions). AK and CA yielded pectins with the highest RG-I proportions (54.8 % and 51.

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Due to the excellent health benefits of rhamnogalacturonan I (RG-I)-enriched pectin, there has been increasing research interest in its gelling properties. To elucidate its structure-gelation relationship, chemical modifications were used to obtain RG-I-enriched pectin (P11). Then, enzymatic modification was performed to obtain debranched pectins GP11 and AP11, respectively.

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  • This text discusses a new method called IES-CYCBD aimed at diagnosing complex bearing faults that are interrelated, making them difficult to identify.
  • The method utilizes an improved envelope spectrum, which helps isolate specific frequency components linked to different fault types by focusing on resonance bands.
  • Simulation and real-world experiments show that the IES-CYCBD method effectively separates and identifies various fault characteristics, even in noisy or complicated scenarios.
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In order to realize the remaining useful life (RUL) prediction of mechanical equipment under different operating conditions, a domain adaption residual separable convolutional neural network (DRSCN) model is proposed in this paper. In the DRSCN model, instead of the traditional convolutional layer, a residual separable convolutional module is developed to improve the feature extraction ability of the model. Moreover, a multi-kernel maximum mean discrepancy metric function and an adversarial learning mechanism are embedded in the DRSCN model to enhance its ability to resist domain shifts, thus improving the cross-domain RUL prediction accuracy of the model.

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The amidation of pectin by amino acids has been widely applied due to its safety and excellent gelling properties. This study systematically examined the effects of pH on the gelling properties of lysine-amidated pectin during amidation and gelation. Pectin was amidated over the range of pH 4-10, and the amidated pectin obtained at pH 10 showed the highest degree of amidation (DA, 27.

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Article Synopsis
  • (-)-Epigallocatechin (EGC) has health benefits but is chemically unstable, leading to a need for better delivery systems.
  • The study created protein-reinforced pectin hydrogel beads (HB) that significantly improved EGC encapsulation and stability, achieving a 92.23% efficiency.
  • The hydrogel’s structure provided protection against degradation and controlled release, offering insights for enhancing tea polyphenol delivery in the food and beverage industry.
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Food bioactives exhibit various health-promoting effects and are widely used in functional foods to maintain human health. After oral intake, bioactives undergo complex biological processes before reaching the target organs to exert their biological effects. However, several factors may reduce their bioavailability.

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Carotenoids in plant foods are sources of pro-vitamin A and nutrients with several health benefits, including antioxidant and anticancer activities. However, humans cannot synthesize carotenoids and must obtain them from the diet, typically via plant foods. We review the chemical changes of carotenoids in plant foods from farm to table and nutrition, including nutrient release and degradation during processing and metabolism in vivo.

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Remaining useful life prediction is of huge significance in preventing equipment malfunctions and reducing maintenance costs. Currently, machine learning algorithms have become hotspots in remaining useful life prediction due to their high flexibility and convenience. However, machine learnings require large amounts of data, and their prediction performance depends heavily on the selection of hyper-parameters.

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A comprehensive understanding of the relationships between the structure and function is critical for the targeted preparation of functional pectins. In this study, we compared the alleviating effects of five orange pectins (200 mg/kg) extracted using acid (), alkali (), cellulase (), acid + cellulase (), and alkali + cellulase () on dextran sodium sulfate-induced acute colitis. The physiological and histopathological indicators revealed that the alleviating effects were most significant for , followed by , , , and .

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Flavonoids have been attracting increasing research interest because of their multiple health promoting effects. However, many flavonoids with similar structures are present in foods, often at low concentrations, which increases the difficulty of their separation and identification. Liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (LC-Q-TOF-MS/MS) has become one of the most widely used techniques for flavonoid detection.

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Citrus fruits are consumed in large quantities worldwide due to their attractive aromas and taste, as well as their high nutritional values and various health-promoting effects, which are due to their abundance of nutrients and bioactives. In addition to water, carbohydrates, vitamins, minerals, and dietary fibers are important nutrients in citrus, providing them with high nutritional values. Citrus fruits are also rich in various bioactives such as flavonoids, essential oils, carotenoids, limonoids, and synephrines, which protect from various ailments, including cancer and inflammatory, digestive, and cardiovascular diseases.

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The purpose of this study is to investigate the potential application of probiotics in the development of novel functional foods based on black garlic. The single-factor analysis (extraction temperatures, solid-to-liquid ratios, and extraction times) and the response surface methodology were firstly used to optimize hot water extraction of soluble solids from black garlic. The optimal extraction conditions were temperature 99.

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Citrus pectin can serve as a naturally digestion-resistant emulsifier, although how it achieves this effect is still unknown. In this study, the upper digestion fate of an emulsion stabilized by different concentrations of citrus pectin, and changes in its interfacial properties during digestion, were investigated. Emulsions stabilized by high-concentration citrus pectin (3 %) were relatively stable during digestion and had a lower free fatty acid (FFA) release rate than emulsions stabilized by low-concentration citrus pectin (1 %).

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Citrus flavanones have the potential to alleviate atherosclerosis. The metabolism and anti-atherosclerosis signaling pathways of four citrus flavanones (naringin, naringenin, hesperidin, and hesperetin) were compared in ApoE mice. Naringin had the most potent anti-atherogenic effect, followed by hesperidin, naringenin, and hesperetin with reductions of 55.

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In recent years, prognostic and health management (PHM) has played an important role in industrial engineering. Efficient remaining useful life (RUL) prediction can ensure the development of maintenance strategies and reduce industrial losses. Recently, data-driven based deep learning RUL prediction methods have attracted more attention.

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Naringin, a major flavonoid in citrus, has potential for preventing atherosclerosis. The presence in the colon of a large amount of naringin after oral intake might affect the gut microbiota. We investigated the role of gut microbiota remodeling in the alleviation of atherosclerosis by naringin.

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Citrus flavonoids consist of diverse analogs and possess various health-promoting effects dramatically depending on their chemical structures. Since different flavonoids usually co-exist in real samples, it's necessary to develop rapid and efficient methods for simultaneous determination of multiple flavonoids. Thin layer chromatography combined with surface enhanced Raman spectroscopy (TLC-SERS) was established to simultaneously separate and detect 14 citrus flavonoids for the first time.

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Citrus, one of the most popular fruits worldwide, contains various functional components, including flavonoids, dietary fibers (DFs), essential oils (EOs), synephrines, limonoids, and carotenoids. The functional components of citrus attract special attention due to their health-promoting effects. Food components undergo complex biotransformation by host itself and the gut microbiota after oral intake, which alters their bioaccessibility, bioavailability, and bioactivity in the host body.

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We previously explored citrus oil emulsion stabilized by citrus pectin. In this report, we characterized key parameters of the citrus pectin mesoscopic structure and their effect on emulsifying capacity, and explored the underlying mechanism by determining the interfacial properties, emulsifying ability, and micromorphology. To generate different mesoscopic structure, citrus pectins were hydrolyzed or regulated by pH and NaCl.

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Sensitive, robust, and highly specific detection of O157:H7, one of the most hazardous foodborne pathogens and the cause of numerous diseases, is needed to ensure public health. Herein, a one-pot step method is reported for the preparation of multifunctional gold nanobones (NBs) (GNR) from gold nanorods (GNRs) comediated by an aptamer (Apt-1) and the signal molecule rhodamine B (RhB) for surface-enhanced Raman scattering detection of O157:H7. The characterized result showed that Apt-1 and RhB were embedded in the gold NBs, and then, this combination exhibited good recognition, excellent stability, and significant Raman signal intensity enhancement.

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Structure and properties of pectin can be affected by extraction methods. In this study, grapefruit peel pectins extracted by HCl (at pH 1 [P1], 2 [P2], and 3 [P3]) and NaOH (at pH 9 [P9], 10 [P10], and 11 [P11]) were prepared and characterized. Atomic force microscopy (AFM) provided direct evidence of complex nano-structural patterns of pectins and revealed cross-linked networks of P10 and P11.

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