Characterization of protective immune responses against induced by intranasal immunization with adhesion and penetration protein.

Drug-resistant is an urgent threat to global public health, and vaccine development is the best long-term strategy for controlling gonorrhea. We have previously shown that adhesion and penetration protein (App) play a role in the adhesion, invasion, and reproductive tract colonization of . Here, we describe the immune response induced by intranasal immunization with passenger and translocator fragments of App.

Type VI secretion system-associated FHA domain protein TagH regulates the hemolytic activity and virulence of Vibrio cholerae.

The type VI secretion system (T6SS) and hemolysin HlyA are important virulence factors in . The forkhead-associated (FHA) domain is a conserved phosphopeptide binding domain that exists in many regulatory modules. The FHA domain protein-encoding gene is conserved in the T6SS gene cluster and regulates the assembly and secretion of the T6SS.