Objective: Adhesion regulating molecule-1 (ADRM1), a 26S proteasome adaptor protein, plays a crucial role in mediating the growth and differentiation of osteoclasts in osteoporosis (OP). However, its involvement in this osteoanabolic effect remains largely uninvestigated.
Methods: experiments, including both gain-of-function and loss-of-function approaches, were conducted in MC3T3-E1 and C3H10T1/2 cells.