Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review.

Postoperative cognitive dysfunction (POCD) is a frequent neurological complication encountered during the perioperative period with unclear mechanisms and no effective treatments. Recent research into the pathogenesis of POCD has primarily focused on neuroinflammation, oxidative stress, changes in neural synaptic plasticity and neurotransmitter imbalances. Given the high-energy metabolism of neurons and their critical dependency on mitochondria, mitochondrial dysfunction directly affects neuronal function.

Heparanase Contributes to Psoriatic Lesions Through Crosstalk with IL-17 Pathway.

Psoriasis is a chronic inflammatory disease that is considered by a network of immunocytes and cytokines. Among all, Th17 cells-derived IL-17 is a critical driving factor in the pathogenesis of psoriasis. Recently, disruption of the extracellular matrix was found to be related to psoriasis progression.

Numerical and experimental study on monitoring coal cracks with PZT sensor.

The rupture of coal pillar can lead to spontaneous combustion or collapse of goaf, which endangers the safety of workers. To explore the relationship between the crack depth of the coal structure and the signal received by the piezoelectric ceramic sensor, the output data of coal samples were analyzed by using the piezoelectric effect, combined with the experiment and ABAQUS simulation. Based on the signal amplitude, the output signal characteristics of the coal model with different crack depths were analyzed, and the evaluation index of coal crack cracking degree (D) was defined.

Recent Progress of Advanced Conductive Metal-Organic Frameworks: Precise Synthesis, Electrochemical Energy Storage Applications, and Future Challenges.

Metal-organic frameworks (MOFs) with diverse composition, tunable structure, and unique physicochemical properties have emerged as promising materials in various fields. The tunable pore structure, abundant active sites, and ultrahigh specific surface area can facilitate mass transport and provide outstanding capacity, making MOFs an ideal active material for electrochemical energy storage and conversion. However, the poor electrical conductivity of pristine MOFs severely limits their applications in electrochemistry.

Different dosages of valaciclovir for the treatment of herpes zoster in adults: A randomized clinical study.

What Is Known And Objective: The dosages of valaciclovir used for herpes zoster treatment recommended by Chinese pharmaceutical companies can differ considerably from those reported in the literature. This randomized clinical study compares the efficacy and safety of different oral valaciclovir doses for the treatment of herpes zoster in adults.

Methods: A total of 214 patients with herpes zoster were enrolled and randomized into two groups according to age: 98 patients in the 18-44-year group (younger patients) and 116 patients in the 45-74-year group (middle-aged and elderly patients).

Variants of CARD14 gene and psoriasis vulgaris in southern Chinese cohort.

Background: Recent mutation analysis identified several missense mutations in CARD14 in psoriasis.

Objectives: We performed the genomic sequence analysis on CARD14 in southern Chinese Han Cantonese with Psoriasis Vulgaris (PsV) to reveal more causative missense mutations.

Methods: A total of 131 patients with PsV and 207 matched controls were included.

First case of congenital idiopathic hypohidrosis in China.

A 43-year-old Chinese man presented with generalized hypohidrosis, which he had had since birth, without obvious abnormalities of other skin appendages except a sparse beard and axillary hairs. The sweat test revealed localized sweating on the face, axillae and palms. Histopathologic examination showed that the sweat glands were absent in the forearm and thigh, but some eccrine and apocrine sweat glands were present in the right axilla.

Cutaneous Chromoblastomycosis Caused by Veronaea botryosa in a Patient with Pemphigus Vulgaris and Review of Published Reports.

Chromoblastomycosis and phaeohyphomycosis represent two poles of a disease spectrum caused by melanized fungi. Veronaea botryosa belongs to a small genus of saprobic fungi that occasionally cause human infections. To date, 11 cases of V.

An association study on the CHRNA5/A3/B4 gene cluster, smoking and psoriasis vulgaris.

Genome-wide association and large cohort studies have consistently linked several single nucleotide polymorphisms (SNPs) located in the CHRNA5/A3/B4 gene cluster to smoking behaviors and nicotine dependence. Smoking is one of the well-established environmental risk factors for psoriasis and also associated with severity of the disease. Then we conduct the study to examine whether the genetic variations related to smoking behavior located in the CHRNA5/A3/B4 gene cluster also predict the risk of psoriasis vulgaris (PV).

Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris.

Smoking, alcohol consumption and higher body mass index (BMI) are well established risk factors for psoriasis and also associated with the clinical traits of the disease. And the genetic influences on these three risk factors indeed exist. Previously studies have demonstrated these risk factors related genetic variants may also play a role in the development of risk factors-related diseases.

Combined effect between CHRNB3-CHRNA6 region gene variant (rs6474412) and smoking in psoriasis vulgaris severity.

Background: Many factors associated with causing psoriasis have been reported, such as the genetic and environmental factors. Smoking is one of the well-established environmental risk factors for psoriasis and also associated with the disease severity. In addition, several studies of psoriasis and psoriatic arthritis have documented gene-environment interactions involving smoking behavior.

Resveratrol triggers protective autophagy through the ceramide/Akt/mTOR pathway in melanoma B16 cells.

Resveratrol (3,5,4'-trihydroxy-trans-stilbene, RSV), a natural polyphenolic compound, is known as a promising anti-cancer agent. In this study, we showed that RSV could inhibit the growth of B16 cells via induction of apoptosis. Moreover, our results showed for the first time that RSV induced autophagy in B16 cells, which might occur through ceramide accumulation and Akt/mTOR pathway inhibition.

Pseudomonas aeruginosa ecthyma gangrenosum in a woman with recurrent Graves' disease.

A 35-year-old woman with postoperative recurrent Graves' disease presented with a 5-day history of a red swelling on the right cheek associated with 4 days of remittent hyperpyrexia. Investigations revealed fever, a gangrenous ulcer on the right cheek, submandibular lymphadenopathy, and thyroid gland enlargement. Her white blood cell count, immunoglobulins, and lymphocyte subsets were unremarkable.

Adiponectin levels in patients with psoriasis: a meta-analysis.

Conflicting results regarding adiponectin levels in patients with psoriasis have been reported. We carried out a meta-analysis on studies which compared adiponectin levels of psoriatic patients with controls. A published work search was performed through PubMed (MEDLINE), EMBASE and the Cochrane Library for articles published in English.

Meta-analysis of IL12B polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritis.

Interleukin 12 (IL-12) is a key player in model systems of autoimmunity. One of the most robust genetic findings is the association of variants in the IL12B gene with psoriasis and psoriatic arthritis (PsA). This study aims to assess whether combined evidence shows the association between IL12B polymorphisms and the susceptibility to psoriasis/PsA.

Association of IL23R polymorphisms with psoriasis and psoriatic arthritis: a meta-analysis.

Background: The association of variants in the IL23R gene with psoriasis and psoriatic arthritis (PsA) is a robust genetic finding

Objectives: To assess whether combined evidence shows the association between IL23R polymorphisms and susceptibility to psoriasis/PsA.

Methods: We conducted a meta-analysis to examine the association between the IL23R rs11209026 (Q381R), rs7530511 (L310P), and rs2201841 polymorphisms and psoriasis/PsA.

Results: Thirteen articles met the inclusion criteria and contributed data to the meta-analysis.

Alcohol consumption and psoriatic risk: a meta-analysis of case-control studies.

Psoriasis is one of the most common dermatological disorders. The association between alcohol consumption and psoriasis has been inconsistent among studies. To examine the magnitude of the risk of developing psoriasis for drinking populations compared to those with non-drinking, and to determine causes of the variation in odds ratios (OR) between various case-control studies, we performed a comprehensive published work search and a meta-analysis of case-control studies considering prevalence.