Publications by authors named "Chengyang Zhu"
Cervical cancer, often driven by high-risk human papillomavirus (HPV) infections such as HPV16 or HPV18, remains a leading cause of cancer-related deaths. HPV16, found in about 90% of cervical cancer patients, harbors key oncogenic related genes (E6, E7, E2, E5) and an upstream regulatory region (URR) that contribute to cancer progression. This study introduces a novel approach using a recombinant oncolytic herpes simplex virus type 1 (HSV-1) named SONC103, armed with a CRISPR/Cas9 gene editing system.
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- Oncolytic virotherapy is a new cancer treatment strategy that uses modified viruses to trigger immune responses specifically against tumors, like the novel oncolytic virus (oHSV1-IL15B) developed from herpes simplex virus-1 (HSV-1) for colon cancer treatment.
- In experiments with mice, oHSV1-IL15B demonstrated significant tumor-fighting effects, especially when combined with another oncolytic virus (oHSV-1-aPD1), resulting in better tumor inhibition and longer survival rates compared to using these treatments alone.
- The study revealed that the combination therapies increased the presence of key immune cells (CD8 and CD4 T cells) and improved the tumor's immune environment, suggesting that combining
CO-selective photoreduction to value-added products is ideal, but its practical application suffers from weak photogenerated carrier separation and insufficient multielectron transport. Herein, we constructed the tricomponent AuNPs@SnO-AuNCs hybrid by decorating Au nanoclusters (AuNCs) on the Au nanoparticle (AuNPs)@SnO core-shell structure. AuNC-NP dual coupling endowed AuNPs@SnO-AuNCs with an excellent CO yield of 64.
View Article and Find Full Text PDFFe-N-C single-atom nanozymes readily achieved discriminative detection of glutathione (GSH) over other biothiols with similar structure due to the difference between POD-like and OXD-like activities regarding the kind of reactive oxygen species. This colorimetric sensor demonstrated the heterogeneity of GSH levels in different cells and accurately monitored cellular GSH fluctuation.
View Article and Find Full Text PDFPatients with hepatic fibrosis (HF) have a high risk of developing liver cirrhosis and hepatocellular carcinoma, and there is an urgent need for preventive strategies to block this process. Previous studies have found that disordered inflammation and oxidative damage play important roles in HF progression, suggesting two attractive therapeutic targets. Herein, a new kind of bioinspired microcapsules with a core-shell structure is generated using microfluidics.
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