Publications by authors named "Chengxin Shang"
Drug-induced hypersensitivity syndrome induced by propylthiouracil: case report and literature review.
Allergy Asthma Clin Immunol
August 2022
Article Synopsis
- DIHS is a serious and rare drug reaction, with antithyroid drugs occasionally implicated, but cases involving propylthiouracil (PTU) are particularly rare.
- A patient presented with severe symptoms, including fever, skin rash, and dysfunction of the liver and kidneys, leading to a diagnosis of PTU-induced DIHS after supportive treatments were initiated.
- This case highlights the importance of recognizing DIHS in patients taking antithyroid drugs and emphasizes the need for timely diagnosis and treatment, marking it as the second documented case worldwide and introducing HLA typing for this condition.
Even though insulin-like growth factor 2 (IGF2) has been reported to be overexpressed in nonalcoholic fatty liver disease (NAFLD), its role in the progression of NAFLD and the potential mechanism remain largely unclear. Using in vitro models, we found that IGF2 was the key overexpressed gene in steatosis, suggesting a possible association between IGF2 and NAFLD. Interestingly, loss-of-function experiments revealed that inhibition of IGF2 protein impaired mitochondrial biogenesis and respiration.
View Article and Find Full Text PDFBackground: Anaplastic thyroid carcinoma (ATC) is a rare malignant tumor with a poor prognosis. However, there is no useful clinical prognostic predictive tool for ATC so far. Our study identified risk factors for survival of ATC and created a reliable nomogram to predict overall survival (OS) and cancer-specific survival (CSS) of patients with ATC.
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