Ultra high speed SPECT bone imaging enabled by a deep learning enhancement method: a proof of concept.

Background: To generate high-quality bone scan SPECT images from only 1/7 scan time SPECT images using deep learning-based enhancement method.

Materials And Methods: Normal-dose (925-1110 MBq) clinical technetium 99 m-methyl diphosphonate (99mTc-MDP) SPECT/CT images and corresponding SPECT/CT images with 1/7 scan time from 20 adult patients with bone disease and a phantom were collected to develop a lesion-attention weighted U-Net (Qin et al. in Pattern Recognit 106:107404, 2020), which produces high-quality SPECT images from fast SPECT/CT images.