Publications by authors named "Chengxiao Guo"
Article Synopsis
- Opioid analgesics, like morphine, can help protect the heart from damage caused by ischaemia/reperfusion injury in patients with chronic heart failure, but the exact mechanisms behind this effect are not yet clear.
- The study investigates the interaction between caveolin-3 (Cav3) and μ opioid receptors in heart tissues and examines how this interaction contributes to cardioprotection when using morphine.
- Results show that both Cav3 and μ receptors are more abundant in failing hearts and disruptors of Cav3 inhibit morphine’s protective effects, indicating that the Cav3/μ receptor complex could be a valuable target for treating heart failure and related ischaemic injuries.
Background: Heart failure is associated with a high rate of mortality and morbidity, and ventricular remodeling invariably precedes heart failure. Ventricular remodeling is fundamentally driven by mechanotransduction that is regulated by both the nervous system and the immune system. However, it remains unknown which key molecular factors govern the neuro/immune/cardio axis that underlies mechanotransduction during ventricular remodeling.
View Article and Find Full Text PDFBackground: Exosomes released into the plasma after brief cardiac ischaemia mediate subsequent cardioprotection. Whether donor exosomes can provide cardioprotection to recipients with chronic heart failure, which confers the highest perioperative risk, is unknown. We examined whether ischaemic preconditioning (IPC)-induced plasma exosomes exerted cardioprotection after their transfer from normal donors to post-infarcted failing hearts.
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