Investigation of the relationship between COVID-19 and pancreatic cancer using bioinformatics and systems biology approaches.

Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, poses a huge threat to human health. Pancreatic cancer (PC) is a malignant tumor with high mortality. Research suggests that infection with SARS-CoV-2 may increase disease severity and risk of death in patients with pancreatic cancer, while pancreatic cancer may also increase the likelihood of contracting SARS-CoV-2, but the link is unclear.

Sulforaphane triggers iron overload-mediated ferroptosis in gastric carcinoma cells by activating the PI3K/IRP2/DMT1 pathway.

Objective: Increasing evidence indicates that prolonged exposure to sulforaphane (SFN) can improve malignancies. However, the role of iron in SFN-triggered death in gastric carcinoma cells and the underlying molecular mechanisms remain unclear. Thus, the current study explored the effects of SFN on iron overload-mediated ferroptosis and the PI3K/IRP2/DMT1 pathway in gastric carcinoma cells.

Association between serum baseline C1q and IgG levels and the efficacy of combined immunotherapy in patients with esophageal squamous cell carcinoma: a retrospective study.

Background: To assess the clinical value of serum complement component 1q (C1q) and immunoglobulin G (IgG) levels in predicting the response to combined immunotherapy in patients with esophageal squamous cell carcinoma.

Methods: We conducted a retrospective study of 44 patients with esophageal squamous cell carcinoma who received combined immunotherapy in our hospital. Serum IgG and C1q levels were collected before and three weeks after immunotherapy treatment, together with other data on clinical and demographic characteristics.

Characterization of a novel class A carbapenemase PAD-1 from Paramesorhizobium desertii A-3-E, a strain highly resistant to β-lactam antibiotics.

Although clinical antibiotic-resistant bacteria have attracted tremendous attention in the microbiology community, the resistant bacteria that persist in natural environments have been overlooked for a longtime. We previously proposed a new species Paramesorhizobium desertii, isolated from the soil of the Taklimakan Desert in China that is highly resistant to most β-lactam antibiotics. To identify potential β-lactamase(s) in this bacteria, we first confirmed the carbapenemase activity in the freeze-thawed supernatant of a P.

Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6.

Taxol (paclitaxel) is a diterpenoid compound with significant and extensive applications in the treatment of cancer. The production of Taxol and relevant intermediates by engineered microbes is an attractive alternative to the semichemical synthesis of Taxol. In this study, based on a previously developed platform, the authors first established taxadiene production in mutant E.

Roseomonas arcticisoli sp. nov., isolated from Arctic tundra soil.

A pale pink, Gram-reaction-negative, non-motile, aerobic bacterium, designated MC 3624T, was isolated from a tundra soil near Ny-Ålesund, Svalbard Archipelago, Norway (78° N). Growth occurred at 10-37 °C (optimum 25-30 °C) and at pH 6.0-9.

Draft Genome Sequence of "Paramesorhizobium deserti" A-3-ET, a Strain Highly Resistant to Diverse β-Lactam Antibiotics.

Here, we report the draft genome sequence of "Paramesorhizobium deserti" A-3-E(T), a strain isolated from the Taklimakan Desert of Xinjiang, China, which is resistant to multiple β-lactam antibiotics and other antibiotics (kanamycin, erythromycin, streptomycin, etc.) as well.

Undibacterium arcticum sp. nov., isolated from arctic alpine soil.

A Gram-stain-negative, aerobic, motile rod-shaped bacterium, designated 6-67T, was isolated from a soil sample collected from Longyearbyen, Svalbard. Its taxonomic position was investigated by genotypic, phenotypic and chemotaxonomic analyses. This isolate grew at 4-28 °C (optimum, 20 °C), at pH 5.

Complete genome sequence of Kocuria flava strain HO-9041, a heavy metal removal bacterium from Xinjiang.

Kocuria flava HO-9041 isolated from the air of Xinjiang of China, is a Gram-positive, aerobic, coccoid, nonencapsulated, non-halophilic, and non-endospore-forming, in the genus Kocuria, and it shows the ability to remove heavy metal. Here, we report the finished and annotated genome sequence of this organism.

sp. nov., isolated from arctic glacial foreland soil.

A novel psychrotolerant bacterium, designed strain M6-79, was isolated from an arctic glacial foreland soil sample collected from Ny-Ålesund in the Svalbard Archipelago, Norway. Cells of strain M6-79 were Gram-stain-negative, rod-shaped and produced a red-pigment. Strain M6-79 was strictly aerobic, non-motile, non-endospore-forming, oxidase-negative and catalase-positive.

Effects of Space Environment on Genome, Transcriptome, and Proteome of Klebsiella pneumoniae.

Background And Aims: The aim of this study was to explore the effects of space flight on Klebsiella pneumoniae.

Methods: A strain of K. pneumoniae was sent to space for 398 h aboard the ShenZhou VIII spacecraft during November 1, 2011-November 17, 2011.

sp. nov., isolated from high-Arctic tundra soil, and emended descriptions of and .

A yellow, Gram-reaction-negative, non-motile, aerobic bacterium, designated D07, was isolated from a tundra soil near Ny-Ålesund, Svalbard archipelago, Norway (78° N). Growth occurred at 4-37 °C (optimum 28-30 °C) and at pH 6.0-9.

Pedobacter ardleyensis sp. nov., isolated from soil in Antarctica.

A red-pigmented, non-motile, Gram-stain-negative, rod-shaped bacterium, strain R2-28T, was isolated from a soil sample collected from Ardley Island, South Shetland Islands, Antarctica, and was characterized taxonomically by using a polyphasic approach. The organism grew optimally at 18 °C in TSB. On the basis of phylogenetic analyses of the 16S rRNA gene sequence, strain R2-28T was most closely related to the genus Pedobacter of the family Sphingobacteriaceae.

Pseudorhodobacter collinsensis sp. nov., isolated from a till sample of an icecap front.

A Gram-stain-negative, rod-shaped, aerobic and non-motile strain, designated 4-T-34T, was isolated from a till sample of Collins icecap front, Antarctica, and its taxonomic position was investigated by genotypic, phenotypic and chemotaxonomic analysis. The isolate grew at 4-30 °C (optimum 20-25 °C), at pH 6.0-10.

Flavobacterium collinsense sp. nov., isolated from a till sample of an Antarctic glacier.

A novel rod-shaped, Gram-stain-negative, non-gliding and aerobic strain surrounded by a multilayer capsule, designated 4-T-2T, was isolated from a till sample of Collins glacier front, Antarctica. The bacterium formed yellow, circular, convex and smooth colonies. Growth occurred at 4-28 °C (optimum18-20 °C), at pH 7.

Sphingoaurantiacus polygranulatus gen. nov., sp. nov., isolated from high-Arctic tundra soil, and emended descriptions of the genera Sandarakinorhabdus, Polymorphobacter and Rhizorhabdus and the species Sandarakinorhabdus limnophila, Rhizorhabdus argentea and Sphingomonas wittichii.

An orange, Gram-reaction-negative and aerobic bacterium, designated MC 3718T, was isolated from a tundra soil near Ny-Ålesund, Svalbard archipelago, Norway (78° N). The cells were motile with either a polar or a subpolar flagellum and reproduced by budding or asymmetrical cell division. Growth occurred at 4-37 °C (optimum 28-30 °C) and at pH 6.

Unraveling adaptation of Pontibacter korlensis to radiation and infertility in desert through complete genome and comparative transcriptomic analysis.

The desert is a harsh habitat for flora and microbial life due to its aridness and strong radiation. In this study, we constructed the first complete and deeply annotated genome of the genus Pontibacter (Pontibacter korlensis X14-1(T) = CCTCC AB 206081(T), X14-1). Reconstruction of the sugar metabolism process indicated that strain X14-1 can utilize diverse sugars, including cellulose, starch and sucrose; this result is consistent with previous experiments.

Risungbinella pyongyangensis gen. nov., sp. nov., a mesophilic member of the family Thermoactinomycetaceae isolated from an agricultural soil sample.

A mesophilic strain, designed MC 210T, was isolated from an agricultural soil sample from Pyongyang, Democratic People's Republic of Korea, and its taxonomic position was investigated by using a polyphasic approach. The novel strain grew well on PYI medium, and no diffusible pigments were produced. The optimum temperature for growth was 37 °C.

Roseovarius antarcticus sp. nov., isolated from a decayed whale bone.

A pale yellow, ovoid- to rod-shaped and budding bacterium, designated strain M-S13-148(T), was isolated from a decayed bone of whale from the eastern coast of King George Island, South Shetlands, Antarctica. Strain M-S13-148(T) exhibited motility, aerobic growth and was Gram-stain-negative. Strain M-S13-148(T) was positive for catalase and oxidase.

Luteolibacter arcticus sp. nov., isolated from high Arctic tundra soil, and emended description of the genus Luteolibacter.

A pale yellow, Gram-reaction-negative, non-motile, aerobic bacterium, designated MC 3726T, was isolated from a tundra soil near Ny-Ålesund, Svalbard Archipelago, Norway (78 °N). Growth occurred at 4-37 °C (optimum 25-30 °C) and at pH 5.0-9.

Parablastomonas arctica gen. nov., sp. nov., isolated from high Arctic glacial till.

A pale yellow, aerobic bacterium, strain M0-2(T), was isolated from a till sample. Its taxonomic position was investigated by using a polyphasic approach. Cells were Gram-stain-negative, rod-shaped and motile.