An efficient synthesis of α-(1,3,5-triazinylthio)-ketones from 1,3-dicarbonyl compounds with 1,3,5-triazine-2-thiols has been developed. The reaction proceeds through the C-C bond cleavage and C-S bond reconstruction of 1,3-dicarbonyl compounds, and β-keto esters, β-keto amides, and 1,3-diones were tolerated. In addition, the annulation of 1,3,5-triazine-2-thiols with chalcones has been achieved for the synthesis of thiazolo[3,2-][1,3,5]triazines.
View Article and Find Full Text PDFObjective: To investigate a simple, safe, and effective surgical approach to treat vascular malformations (VM).
Methods: Tissues of vein, heart, liver, and kidney were obtained and pathologically observed from 30 rabbits whose central veins of the ears were retained with copper needles, and the concentration of Cu in serum was measured. In the clinical research, 3 methods were employed to treat 89 patients with VM: (1) retaining copper needles alone; (2) ligaturing lesions and retaining copper needles; (3) retaining copper needles charged with direct current (DC).
Zhonghua Zheng Xing Wai Ke Za Zhi
July 2006
Unlabelled: OBJECTIVE; To evaluate a technique with retained copper needles for the treatment of venous malformations.
Methods: With 78 venous malformation cases, there were three methods were applied for the treatment respectively, including copper needles in the lesion only, vascular ligation with the copper needles in the lesion, and electrical puncture with the copper needles in the lesion.
Results: There were totally 96% effective rate achieved in this clinical data.