Publications by authors named "Chenguang Su"
Background: Numerous observational studies have shown a potential association between metabolic dysfunction-associated steatotic liver disease (MASLD) and gastroesophageal reflux disease (GERD). However, causality is unclear. This study utilized genome-wide association study (GWAS) genetic data to explore the causal relationship between MASLD and GERD in European and East Asian populations.
View Article and Find Full Text PDFObjective: To construct a stable rat portal vein thrombosis (PVT) model and explore the time window of urokinase thrombolytic therapy on this basis.
Methods: Constructing a rat PVT model by combining anhydrous ethanol disruption of portal endothelium with stasis of blood flow. Forty-eight rats after PVT modeling were divided into control group and experimental group, with 24 rats in each group.
Article Synopsis
- Immune Checkpoint Inhibitors (ICIs) are being studied as a treatment for unresectable hepatocellular carcinoma (uHCC), but their effectiveness compared to standard targeted therapies is unclear.
- A meta-analysis of ten high-quality studies with over 5,500 patients showed ICIs resulted in better overall survival (OS) and progression-free survival (PFS) compared to targeted therapies.
- The analysis indicated that while ICIs had a higher objective response rate (ORR) and disease control rate (DCR), they also maintained a comparable safety profile with fewer severe treatment-related adverse events.
Background: For resectable hepatocellular carcinoma (HCC), radical hepatectomy is commonly used as a curative treatment. However, postoperative recurrence significantly diminishes the overall survival (OS) of HCC patients, especially with microvascular invasion (MVI) as an independent high-risk factor for recurrence. While some studies suggest that postoperative adjuvant therapy may decrease the risk of recurrence following liver resection in HCC patients, the specific role of adjuvant therapies in those with MVI remains unclear.
View Article and Find Full Text PDFAim: The aim of this study was to evaluate the efficacy and safety of the anticoagulants for the prevention of portal vein system thrombosis (PVST) in patients with cirrhosis after splenectomy and explore the optimal time of anticoagulant administration.
Methods: A systematic literature search was performed using PubMed, Embase and China Biology Medicine disc (CBM)databases, so as to screen out studies comparing the prognoses between cirrhotic post-splenectomy patients treated with and without anticoagulants. The parameters that were analyzed included the incidence of PVST and postoperative bleeding.
Neutrophil extracellular traps (NETs) as special release products of neutrophils have received extensive attention. They are composed of decondensed chromatin and coated with nucleoproteins, including histones and some granulosa proteins. NETs can form a network structure to effectively capture and eliminate pathogens and prevent their spread.
View Article and Find Full Text PDFArticle Synopsis
- Beads in optical tweezers align along the light path, making it hard to count them using bright-field microscopy, which complicates single-molecule force measurements.
- A new video processing method using normalized cross-correlation and image enhancement techniques enables real-time counting of trapped micro-objects, detecting changes in image similarity as beads enter the trap.
- This method can identify up to four beads individually and is effective even with the trap's slight movement, proving to be a sensitive and simple solution for monitoring changes in optical trapping experiments.