Detecting carcinoembryonic antigen based on the aggregation-induced emission enhancement effect.

In this study, a novel label-free fluorescent aptasensor with an aggregation-induced emission enhancement effect was developed and applied for the detection of carcinoembryonic antigen (CEA). The sensor has a simple detection mechanism, easy operation, high sensitivity (with low limit of detection of 1 pg mL), good selectivity, and wide linear range (0.003-10 ng mL).

Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy.

Background: Inflammation contributes to cardiovascular complications in type 2 diabetes, which are often characterized by microvascular alterations. We investigated whether myeloid-related protein 8/14 complex (MRP8/14) secreted by transmigrating monocytes and granulocytes may represent a biomarker for microvascular alterations in patients with type 2 diabetes and nephropathy.

Methods: MRP8/14 was measured in 43 patients with type 2 diabetes and nephropathy.

Comparison of three measures of the ankle-brachial blood pressure index in a general population.

The ankle-brachial blood pressure index (ABI) predicts cardiovasular disease. To our knowledge, no study has compared manual ABI measurements with an automated electronic oscillometric method in a population sample. We enrolled 946 residents (50.