Effect of hyperthermia combined with opioids on cancer pain control and surgical stress in patients with gastrointestinal cancer.

Background: Surgical palliative surgery is a common method for treating patients with middle and late stage gastrointestinal tumors. However, these patients generally experience high levels of cancer pain, which can in turn stimulate the body's stress and undermine the effect of external surgery. Although opioid drugs have a significantly positive effect on controlling cancer pain, they can induce adverse drug reactions and potential damage to the body 's immune function.

Risk factor analysis and predictive model construction for bone metastasis in newly diagnosed malignant tumor patients.

Objective: To identify risk factors for bone metastasis in patients with newly diagnosed malignant tumor and to develop a prediction model.

Methods: Clinical data from 232 patients with newly diagnosed malignant tumors were analyzed to screen for risk factors associated with bone metastasis. A nomogram prediction model was constructed using R software.

Analysis for drug metabolism-related prognostic subtypes and gene signature in liver cancer.

Liver cancer is highly heterogeneous and has a poor prognosis. We aimed to identify a drug metabolism-related prognostic subtype and a gene signature as references for prognosis and therapy options for patients with liver cancer. Patient information was collected from online databases.

Enhancement of NK cells proliferation and function by Shikonin.

Context: Shikonin is a kind of naphthoquinone compound found mainly in Lithospermum erythrorhizon Sieb,et Zucc. Previous studies have shown that Shikonin has anti-tumor, anti-inflammatory and extensive pharmacological effects. According to new studies, Shikonin could also modulate the immune system function, but the effect to NK (nature killer) cells is yet unknown.

Both FOXP1 and p65 expression are adverse risk factors in diffuse large B-cell lymphoma: a retrospective study in China.

The purpose of this study was to investigate the clinical significance of FOXP1 and p65 expression in diffuse large B-cell lymphoma (DLBCL). Immunohistochemistry was performed to determine the expression of FOXP1 and p65 protein in 92 DLBCL tissues and analyze their correlations with clinicopathological features or prognosis of patients. The survival was assessed by the Kaplan-Meier method and proportional hazards model.

Relationship between RGS5 expression and differentiation and angiogenesis of gastric carcinoma.

Aim: To explore the regulator of G-protein signaling 5 (RGS5) expression in gastric carcinoma and its association with differentiation and microvascular density (MVD).

Methods: Expression of RGS5 and CD34 were examined in 76 cases of gastric carcinoma, including 22 cases with lymph node metastasis and 54 cases without lymph node metastasis determined by immunohistochemistry (IHC). MVD was assessed using CD34 monoclonal antibody.