Publications by authors named "Chengqi Jin"
Background And Objective: Olaparib + abiraterone has a combined antitumor effect in metastatic castration-resistant prostate cancer (mCRPC), but the efficacy of this combination in patients with DNA damage repair (DDR)-deficient mCRPC progressing after abiraterone is unknown. Our aim was to compare the efficacy of olaparib + abiraterone versus olaparib monotherapy for patients with DDR-deficient mCRPC progressing after abiraterone.
Methods: The study included 86 consecutive patients with DDR-deficient mCRPC progressing after abiraterone: 34 received olaparib + abiraterone, and 52 received olaparib monotherapy.
Article Synopsis
- * The study investigated how anisodamine helps prevent kidney damage by looking into its activation of the ERK signaling pathway, which aids in repairing renal epithelial cells after injury.
- * Results indicated that anisodamine improved kidney function and reduced injury by increasing protective proteins and decreasing harmful ones, but these protective effects were hindered when an ERK inhibitor was used.