Non-linear association between AKI alert detection rate by physicians and medical costs.

Background: Acute kidney injury (AKI) is associated with high mortality rates and long-term adverse outcomes and significantly increases medical costs. The AKI electronic alert system built the AKI diagnostic algorithm into the medical system, along with automated collection of key indications and generation of alerts. However, the relationship between the AKI electronic alert system and medical costs is still unknown.

Analgesic efficacy of transcranial combined peripheral magnetic stimulation in chronic nonspecific low back pain: a fNIRS study.

Background: Magnetic stimulation has a potential therapeutic effect on patients with chronic nonspecific low back pain (CNLBP). However, the efficacy and underlying brain mechanisms of closed-loop magnetic stimulation for CNLBP remain unclear.

Aim: This study aims to investigate the analgesic efficacy and brain activation of repetitive transcranial magnetic stimulation (rTMS) combined with repetitive peripheral magnetic stimulation (rPMS) in patients with CNLBP.

Hexokinase 2 Suppression Alleviates the Catabolic Properties in Osteoarthritis via HMGA2 and Contributes to Pulsed Electromagnetic Field-mediated Cartilage Protection.

Abnormalities in glycolytic pathways are prominent factors in the pathogenesis of osteoarthritis (OA). The key glycolytic enzyme Hexokinase 2 (HK2) is highly expressed in chondrocytes in OA; however, its role remains unclear. Pulsed electromagnetic field (PEMF) is commonly used for the treatment of OA.

The effect of bilateral knee osteoarthritis on gait symmetry during walking on different heights of staircases.

Knee osteoarthritis (KOA) can lead to asymmetric gait, which is one of many potential risk factors for falls. Particularly, those working in industrial environments are often required to navigate stairs, yet there is limited understanding of how KOA impacts gait symmetry during stair negotiation. The goal of this study was to find out how negotiating stairs affects the balance of walking in people with bilateral KOA by measuring ground reaction forces (GRFs).

An evidence-based tailored eHealth patient education tool for patients with knee osteoarthritis: A randomized controlled trial.

Background: An evidence-based eHealth education tool was developed for patients with knee osteoarthritis (KOA). This study aimed to evaluate the long-term effectiveness on patient knowledge level and analyzed the patient's satisfaction with the proposed tool.

Methods: A two-arm randomized controlled trial was performed, with 218 KOA patients allocated 1:1 to two groups by balanced block randomization.

Unlocking the Potential of Extracellular Vesicles in Cardiovascular Disease.

Extracellular vesicles (EVs) are micro-nanoscale biological particles encapsulated by phospholipid bilayers, which regulate cell migration, angiogenesis and tumour cell growth by transmitting various biomolecules such as nucleic acids and proteins. EVs are composed of exosomes, microparticles and apoptotic bodies. Its benefits pass through biofilms and are not degraded by various enzymes, so it can be used as a biomarker in potential diseases and has attracted much attention from researchers.

Narratives of Chinese kindergarteners with Autism spectrum disorder: Comparison with typically developing children.

Autism spectrum disorder (ASD) is an early-onset neurodevelopmental disorder characterised by highly heterogeneous language abilities. These variations necessitate sensitive and comprehensive assessments, with narrative analysis being an effective method. This study aimed to examine the micro- and macrostructural aspects of narratives of Mandarin-speaking children with ASD.

Mapping the evolution and frontiers of : a bibliometric analysis and literature review.

Background And Objective: While bibliometric studies of single journals have been conducted, bibliometric mapping has not yet been used to analyze the literature published by the (). This study aimed to comprehensively review all publications of from its inception to 2024 and provide a detailed overview of its main publication characteristics.

Methods: This study analyzed publications from spanning 2012 to 2024 using CiteSpace, VOSviewer, and the 'Bibliometrix' package in R.

Association between weight-adjusted-waist index and long-term prognostic outcomes in cardiovascular disease patients: results from the NHANES 1999-2018 study.

Background: As cardiovascular disease (CVD) morbidity and mortality increase yearly, this study aimed to explore the potential of the weight-adjusted-waist index (WWI) and its relation to long-term mortality in patients with CVD.

Methods: The diagnosis of CVD was based on standardized medical condition questionnaires that incorporated participants' self-reported physician diagnoses. WWI (cm/√kg) is a continuous variable and calculated as waist circumference (WC, cm) divided by square root of body weight (kg).

Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer.

Reactive oxygen species (ROS)-responsive drug delivery systems (DDSs) have garnered significant attention in cancer research because of their potential for precise spatiotemporal drug release tailored to high ROS levels within tumors. Despite the challenges posed by ROS distribution heterogeneity and endogenous supply constraints, this review highlights the strategic alliance of ROS-responsive DDSs with photodynamic therapy (PDT), enabling selective drug delivery and leveraging PDT-induced ROS for enhanced therapeutic efficacy. This review delves into the biological importance of ROS in cancer progression and treatment.

Research Progress and Hot Topics in Telerehabilitation for Hip or Knee Arthroplasty.

Objective: Many publications on telerehabilitation for hip or knee arthroplasty have been published in recent years. However, no specific studies have attempted to characterize research hotspots, global research collaborations, or trends related to telerehabilitation after hip or knee arthroplasty. Therefore, the aim of this bibliometric analysis was to provide an overview of the current status of research and map the research landscape on telerehabilitation for joint replacement to understand current trends, identify research gaps, and guide future research directions.

Histone lactylation in macrophage biology and disease: from plasticity regulation to therapeutic implications.

Epigenetic modifications have been identified as critical molecular determinants influencing macrophage plasticity and heterogeneity. Among these, histone lactylation is a recently discovered epigenetic modification. Research examining the effects of histone lactylation on macrophage activation and polarization has grown substantially in recent years.

Mapping the scientific landscape and evolution of the International Journal of Surgery : a scientometric analysis (2004-2024).

Aim: The purpose of this study was to analyze the publication characteristics and development of the International Journal of Surgery (IJS) over its 20-year history.

Methods: This study included articles published in IJS during the 20 years from 2004 to 2024. The data were analyzed using the Citespace, VOS viewer, and the 'Bibliometrix' package in R software.

Mapping the Evolution of Digital Health Research: Bibliometric Overview of Research Hotspots, Trends, and Collaboration of Publications in JMIR (1999-2024).

Background: While bibliometric studies of individual journals have been conducted, to the best of our knowledge, bibliometric mapping has not yet been utilized to analyze the literature published by the Journal of Medical Internet Research (JMIR).

Objective: In celebration of the journal's 25th anniversary, this study aimed to review the entire collection of JMIR publications from 1999 to 2024 and provide a comprehensive overview of the main publication characteristics.

Methods: This study included papers published in JMIR during the 25-year period from 1999 to 2024.

Telehealth-Supported Exercise or Physical Activity Programs for Knee Osteoarthritis: Systematic Review and Meta-Analysis.

Background: The integration of telehealth-supported programs in chronic disease management has become increasingly common. However, its effectiveness for individuals with knee osteoarthritis (KOA) remains unclear.

Objective: This study aimed to assess the effectiveness of telehealth-supported exercise or physical activity programs for individuals with KOA.

Mechanisms and applications of the regenerative capacity of platelets-based therapy in knee osteoarthritis.

Osteoarthritis (OA) is the most prevalent joint disease in the elderly population and its substantial morbidity and disability impose a heavy economic burden on patients and society. Knee osteoarthritis (KOA) is the most common subtype of OA, which is characterized by damage to progressive articular cartilage, synovitis, and subchondral bone sclerosis. Most current treatments for OA are palliative, primarily aim at symptom management, and do not prevent the progression of the disease or restore degraded cartilage.

Development and validation of a novel screening tool for deep vein thrombosis in patients with spinal cord injury: A five-year cross-sectional study.

Study Design: Cross-sectional study.

Objectives: Deep vein thrombosis (DVT) presents a significant risk of complication in patients with spinal cord injury (SCI), necessitating accurate screening methods. While the Caprini Risk Assessment Model (Caprini RAM) has seen extensive use for DVT screening, its efficacy remains under scrutiny.

Evaluation and management of knee osteoarthritis.

Knee osteoarthritis (KOA) significantly contributes to the global disability burden, with its incidence expected to escalate by 74.9% by 2050. The urgency to comprehend and tackle this condition is critical, necessitating an updated and thorough review of KOA.

Associations of RBC counts and incidence of DVT in patients with spinal cord injury: a five year observational retrospective study.

Background: The role of red blood cell (RBC) counts as potential independent risk factors for deep vein thrombosis (DVT) in patients with spinal cord injury (SCI) remains uncertain. This study aims to clarify the associations between RBC counts and DVT incidence among this population.

Methods: A retrospective analysis was performed on 576 patients with SCI admitted to the rehabilitation medicine department from January 1, 2017 to December 31, 2021.