Benefit from Almonertinib after Osimertinib treat EGFR 19 exon deletion NSCLC induced Severe rash: a case report.

Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), has been recommended as a first-line treatment of EGFR-positive non-small cell lung cancer (NSCLC). Skin rash is one of the most common side effects of osimertinib, and can have an impact on patients' quality of life and follow-up. However, there are few reports on the safety and efficacy of switching therapy with osimertinib and the other three generations of TKIs.

Insight into the plant-associated bacterial interactions: Role for plant arsenic extraction and carbon fixation.

This study investigated the interactions between rhizosphere and endosphere bacteria during phytoextraction and how the interactions affect arsenic (As) extraction and carbon (C) fixation of plants. Pot experiments, high-throughput sequencing, metabonomics, and network analysis were integrated. Results showed that positive correlations dominated the interconnections within modules (>95 %), among modules (100 %), and among keystone taxa (>72 %) in the bacterial networks of plant rhizosphere, root endosphere, and shoot endosphere.

Encrypted information reading technology at the micro/nano scale based on surface plasma-driven reactions.

The plasma exciton induced photocatalytic reaction has considerable potential in terms of controllability and selectivity. In this paper, with the advantage of Raman fingerprinting, the localized photocatalytic reaction driven by surface plasmons is realized by the writing and reading process of encrypted information at the micro/nano scale. A layer of probe molecules (4-nitrobenzenethiol, 4-NBT) was assembled on a gold nanoporous array grown on porous anodic aluminium oxide (AAO) membranes.

Plasmon-driven photocatalytic reaction based on gold microsphere array.

Plasma-driven photocatalytic reactions have great research value in the fields of energy utilization, environmental pollution treatment and micro-nano information encryption. In most cases, the substrates used to study photocatalytic reactions are dispersed and disordered, which leads to poor signal reproducibility and makes it difficult to realize applications in the field of quantitative analysis. In this paper, two different sizes of polystyrene (PS) microspheres were used as templates to prepare gold microsphere arrays (Au MA) with homogeneous particle size and regular arrangement.

LncRNA UCA1 promotes SOX12 expression in breast cancer by regulating mA modification of miR-375 by METTL14 through DNA methylation.

Breast cancer, a multifactorial disease, represents one of the leading causes of cancer-related morbidity and mortality in women. This study set out to elucidate the underlying mechanism by which lncRNA UCA1 affects the mA modification of miR-375 by mediating the DNA methylation of METTL14 and then altering SOX12 expression in breast cancer. First, the expression patterns of lncRNA UCA1, miR-375, and apoptosis-related factors were quantitated by means of RT-qPCR and western blot analysis.

Carbon ion (C) irradiation induces the expression of Klrk1 in lung cancer and optimizes the tumor microenvironment based on the NKG2D/NKG2D-Ls pathway.

With the identification of "negative immune regulation" defects in the immune system and the continuous improvement of immunotherapy, natural killer cells (NK) have received more attention, especially as tools in combined immunotherapy. Carbon ions (C) have become the ideal radiation for combined immunotherapy due to their significant radiobiological advantages and synergistic effects. The purpose of this study was to explore the NK cell-mediated cytotoxicity pathway and related mechanisms in lung cancer induced by carbon ion irradiation.

The m6A methyltransferase METTL3 controls epithelial-mesenchymal transition, migration and invasion of breast cancer through the MALAT1/miR-26b/HMGA2 axis.

Background: Previous studies have revealed the key functions of N6-methyladenosine (m6A) modification in breast cancer (BC). MALAT1 as a highly m6A modified lncRNA associated with cancer development and metastasis, but the functional relevance of m6A methyltransferase and MALAT1 in BC is still unknown. Here, our study investigated the effects of the novel m6A methyltransferase METTL3 on epithelial-mesenchymal transition (EMT) in BC via the MALAT1/miR-26b/HMGA2 axis.

Plasmon-driven photocatalytic properties based on the surface of gold nanostar particles.

Surface plasmon resonance (SPR) generated in gold nanoparticles can induce the conversion of p-Aminothiophenol (PATP) molecules into p,p'-dimercaptoazobenzene (DMAB) molecules by coupling reaction under the action of excitation light. Molecular detection of samples by surface enhanced Raman spectroscopy (SERS) techniques allows the study of their plasma-driven photocatalytic reaction processes. In this study, we used gold nanostars (GNS) as the substrate to study its catalytic performance and sensitivity.

Irradiation-Induced Changes in the Immunogenicity of Lung Cancer Cell Lines: Based on Comparison of X-rays and Carbon Ions.

Increasing the immunogenicity of tumors is considered to be an effective means to improve the synergistic immune effect of radiotherapy. Carbon ions have become ideal radiation for combined immunotherapy due to their particular radiobiological advantages. However, the difference in time and dose of immunogenic changes induced by Carbon ions and X-rays has not yet been fully clarified.

MicroRNA-138-5p inhibits cell migration, invasion and EMT in breast cancer by directly targeting RHBDD1.

Background: Accumulating studies have identified that microRNAs (miRNAs) are novel regulators acting as tumor suppressors or oncogenes in tumor progression. The aim of the study is to investigate the functional roles of miR-138-5p in breast cancer (BC) cells and explore the underlying mechanisms by identifying its target gene.

Methods And Results: Our results first showed that miR-138-5p expression was remarkably decreased in BC tissues and cells using quantitative real-time PCR analysis.

Accuracy of intercellular adhesion molecule-1 for diagnosing sepsis: A systematic review and meta-analysis protocol.

Background: Sepsis is a complex and life-threatening systemic disease. A positive blood culture is the criterion standard of diagnosis for sepsis; however, it does not produce results for 24 to 72 hours. Besides, the clinical manifestations of sepsis are variable and nonspecific.

[Proximal humeral fractures in children choose different surgical methods].

Objective: To observe the therapeutic effect of open reduction Kirschner wire fixation and open reduction external fixation in the treatment of the proximal humeral fractures in children.

Methods: Sixty two patients with proximal humeral fractures had received Kirschner wire fixation and external fixation in our hospital from Oct. 2010 to Aug.

[Outcomes of different operations for distal forearm fractures in children].

Objective: To explore the treatment outcomes of plate internal and external fixations for distal forearm fractures in children.

Methods: From July 2010 to September 2013, a total of 89 children were operated for distal forearm ulnar and radial fractures, including plate fixation (n=46) and external fixation (n=43). Two groups were evaluated in terms of operative duration, bleeding volume, length of incision, hospitalization length, fracture healing time, postoperative complications and Berton evaluation criteria.

[The design and transposition principles of expanded flap for treatment of cheek skin-soft tissue defect].

Objective: To explore an ideal method for repairing the skin-soft tissue defects according to the different anatomical units of cheek, and find reasonable design principles to transfer the expanded flaps.

Methods: According to the location of the defect, we placed 1-3 appropriate expanders nearby, when the flap expanded enough we adopted advanced skin flaps, rotation-advanced skin flaps or transposition skin flaps to repair the defect. In this group of 269 cases, the defects were secondary to hemangioma, various scars, nevus or nevus excision.