Publications by authors named "Chengnuo Wang"
Glucose metabolism has been well understood for many years, but some intriguing questions remain regarding the subcellular distribution, transport, and functions of glycolytic metabolites. To address these issues, a living cell metabolic monitoring technology with high spatiotemporal resolution is needed. Genetically encoded fluorescent sensors can achieve specific, sensitive, and spatiotemporally resolved metabolic monitoring in living cells and in vivo, and dozens of glucose metabolite sensors have been developed recently.
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- * The researchers developed high-performance fluorescent biosensors called sensitive to arginine (STAR) that allow for real-time monitoring of arginine levels in cells, mice, and clinical samples.
- * Using STAR, they discovered the influence of different amino acids on arginine levels and found that serum arginine levels tend to rise with age, which could help in assessing the progression of conditions like vitiligo.
Identification of compounds to modulate NADPH metabolism is crucial for understanding complex diseases and developing effective therapies. However, the complex nature of NADPH metabolism poses challenges in achieving this goal. In this study, we proposed a novel strategy named NADPHnet to predict key proteins and drug-target interactions related to NADPH metabolism via network-based methods.
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