A reinforced lunar dynamo recorded by Chang'e-6 farside basalt.

The evolution of the lunar dynamo is essential for deciphering the deep interior structure, thermal history, and surface environment of the Moon. Previous palaeomagnetic investigations on samples returned from the nearside of the Moon have established the general variation of the lunar magnetic field. However, limited spatial and temporal palaeomagnetic constraints leave the evolution of the lunar dynamo ambiguous.

Climate and cultural evolution drove Holocene cropland change in the Huai River Valley, China.

As an important way of maximizing land productivity by growing more than one crop type in the same field, mixed cropping has been an effective option for sustaining population growth under different climatic conditions since prehistoric period. We used a combination of archaeological data and an improved prehistoric land use model (PLUM) to quantitatively reconstruct spatiotemporal changes in cropland types and areas in the Huai River Valley of China, a core region of mixed cropping during the Holocene. The total cropland area increased more than 25 times during 8-2 ka BP, with northward expansion of rice-dominated cultivation during 5-4 ka BP and southward expansion of dry-dominated cultivation after 4 ka BP.

New Late Pleistocene age for the Homo sapiens skeleton from Liujiang southern China.

The emergence of Homo sapiens in Eastern Asia is a topic of significant research interest. However, well-preserved human fossils in secure, dateable contexts in this region are extremely rare, and often the subject of intense debate owing to stratigraphic and geochronological problems. Tongtianyan cave, in Liujiang District of Liuzhou City, southern China is one of the most important fossils finds of H.

Super-Ionic Conductor Soft Filler Promotes Li Transport in Integrated Cathode-Electrolyte for Solid-State Battery at Room Temperature.

Composite polymer solid electrolytes (CPEs), possessing good rigid flexible, are expected to be used in solid-state lithium-metal batteries. The integration of fillers into polymer matrices emerges as a dominant strategy to improve Li transport and form a Li-conducting electrode-electrolyte interface. However, challenges arise as traditional fillers: 1) inorganic fillers, characterized by high interfacial energy, induce agglomeration; 2) organic fillers, with elevated crystallinity, impede intrinsic ionic conductivity, both severely hindering Li migration.

Completing the loop of the Late Jurassic-Early Cretaceous true polar wander event.

The reorientation of Earth through rotation of its solid shell relative to its spin axis is known as True polar wander (TPW). It is well-documented at present, but the occurrence of TPW in the geologic past remains controversial. This is especially so for Late Jurassic TPW, where the veracity and dynamics of a particularly large shift remain debated.

Earliest Prepared core technology in Eurasia from Nihewan (China): Implications for early human abilities and dispersals in East Asia.

Organized flaking techniques to obtain predetermined stone tools have been traced back to the early Acheulean (also known as mode 2) in Africa and are seen as indicative of the emergence of advanced technical abilities and in-depth planning skills among early humans. Here, we report one of the earliest known examples of prepared core technology in the archaeological record, at the Cenjiawan (CJW) site in the Nihewan basin of China, dated 1.1 Mya.

Bipolar Polymeric Protective Layer for Dendrite-Free and Corrosion-Resistant Lithium Metal Anode in Ethylene Carbonate Electrolyte.

The unstable interface between Li metal and ethylene carbonate (EC)-based electrolytes triggers continuous side reactions and uncontrolled dendrite growth, significantly impacting the lifespan of Li metal batteries (LMBs). Herein, a bipolar polymeric protective layer (BPPL) is developed using cyanoethyl (-CHCHC≡N) and hydroxyl (-OH) polar groups, aiming to prevent EC-induced corrosion and facilitating rapid, uniform Li ion transport. Hydrogen-bonding interactions between -OH and EC facilitates the Li desolvation process and effectively traps free EC molecules, thereby eliminating parasitic reactions.

Application scenario-oriented molecule generation platform developed for drug discovery.

Design of molecules for candidate compound selection is one of the central challenges in drug discovery due to the complexity of chemical space and requirement of multi-parameter optimization. Here we present an application scenario-oriented platform (ID4Idea) for molecule generation in different scenarios of drug discovery. This platform utilizes both library or rule based and generative based algorithms (VAE, RNN, GAN, etc.

LiPF Induces Phosphorization of Garnet-Type Solid-State Electrolyte for Stable Lithium Metal Batteries.

Garnet solid electrolyte Li La Zr Ta O (LLZTO) is an excellent inorganic ceramic-type solid electrolyte; however, the presence of Li CO impurities on its surface hinders Li-ion transport and increases the interface impedance. In contrast to traditional methods of mechanical polishing, acid corrosion, and high-temperature reduction for removing Li CO , herein, a straightforward "waste-to-treasure" strategy is proposed to transform Li CO into Li PO and LiF in LiPF solution under 60 °C. It is found that the formation of Li PO during LLZTO pretreatment facilitates rapid Li-ion transport and enhances ionic conductivity, and the LLZTO/PAN composite polymer electrolyte shows the highest Li-ion transference number of 0.

Total Structure, Electronic Structure and Catalytic Hydrogenation Activity of Metal-Deficient Chiral Polyhydride Cu Nanoclusters.

Accurate identifying and in-depth understanding of the defect sites in a working nanomaterial could hinge on establishing specific defect-activity relationships. Yet, atomically precise coinage-metal nanoclusters (NCs) possessing surface vacancy defects are scarce primarily owing to challenges in the synthesis and isolation of such defective NCs. Herein we report a mixed-ligand strategy to synthesizing an intrinsically chiral and metal-deficient copper hydride-rich NC [Cu H (PET) (TPP) ] (Cu H ).

Dynamic link between Neo-Tethyan subduction and atmospheric CO changes: insights from seismic tomography reconstruction.

Volcanic arc degassing contributes significantly to atmospheric CO levels and therefore has a pivotal impact on paleoclimate changes. The Neo-Tethyan decarbonation subduction is thought to have played a major role in Cenozoic climate changes, although there are still no quantifiable restrictions. Here we build past subduction scenarios using an improved seismic tomography reconstruction method and calculate the subducted slab flux in the India-Eurasia collision region.

Plio-Pleistocene deep-sea ventilation in the eastern Pacific and potential linkages with Northern Hemisphere glaciation.

Antarctic bottom water (AABW) production is a key factor governing global ocean circulation, and the present disintegration of the Antarctic Ice Sheet slows it. However, its long-term variability has not been well documented. On the basis of high-resolution chemical scanning of a well-dated marine ferromanganese nodule from the eastern Pacific, we derive a record of abyssal ventilation spanning the past 4.

Low dinosaur biodiversity in central China 2 million years prior to the end-Cretaceous mass extinction.

Whether or not nonavian dinosaur biodiversity declined prior to the end-Cretaceous mass extinction remains controversial as the result of sampling biases in the fossil record, differences in the analytical approaches used, and the rarity of high-precision geochronological dating of dinosaur fossils. Using magnetostratigraphy, cyclostratigraphy, and biostratigraphy, we establish a high-resolution geochronological framework for the fossil-rich Late Cretaceous sedimentary sequence in the Shanyang Basin of central China. We have found only three dinosaurian eggshell taxa (, , and ) representing two clades (Oviraptoridae and Hadrosauridae) in sediments deposited between ∼68.

Multi-channel GCN ensembled machine learning model for molecular aqueous solubility prediction on a clean dataset.

This study constructed a new aqueous solubility dataset and a solubility regression model which was ensembled by GCN and machine learning models. Aqueous solubility is a key physiochemical property of small molecules in drug discovery. In the past few decades, there have been many studies about solubility prediction.

A combination of eye-gaze and head-gaze interactions improves efficiency and user experience in an object positioning task in virtual environments.

Eye-gaze and head-gaze are two hands-free interaction modes in virtual reality, each of which has demonstrated different strengths. Selecting suitable interaction modes in different scenarios is important to achieve efficient interaction in virtual scenes. This study compared the movement time in an object positioning task by examining eye-gaze interaction and head-gaze interaction in various conditions.

Accurate calculation of absolute free energy of binding for SHP2 allosteric inhibitors using free energy perturbation.

Accurate prediction of binding affinity is a primary objective in structure-based drug discovery. A free energy perturbation (FEP) method based on molecular dynamics simulation shows great promise for protein-ligand binding affinity predictions. However, accurate calculation of binding affinity for allosteric inhibitors remains unknown and elusive, which hampers the discovery of allosteric inhibitors.

Effective Reaction-Based Strategy for Kinase Targets: A Case Study on MERTK Inhibitors.

Reaction-based design is the computational generation of novel molecular structures by linking building blocks using reaction vectors derived from chemistry knowledge. In this work, we first adopted a recurrent neural network (RNN) model to generate three groups of building blocks with different functional groups and then constructed an in silico target-focused combinatorial library based on chemical reaction rules. Mer tyrosine kinase (MERTK) was used as a study case.

Controllable spontaneous resolution in ultrasmall Cu-Ag bimetallic cluster ion pairs from achiral components.

Bimetallic cluster ion pairs containing a quaternary phosphonium and an ultrasmall CuAg anionic cluster protected by thiolates: (PPhR'')[CuAg(SR')] (R'SH = cyclohexylthiol (CySH), R'' = Ph, 1; Me, 2; Et, 3; Pr, 4; R'SH = -butylthiol (BuSH) and R'' = Ph, 5) were reported. Without any chiral source, 1 crystallizes as conglomerate crystals with homochiral packings and spontaneous resolution occurs, while four other clusters 2-5 crystallize as racemic crystals with heterochiral packings. These results indicate that racemic and homochiral crystallization in the cluster system could be controlled through fine-tuning internal achiral structural components.

Enhancing Interfacial Contact in Solid-State Batteries with a Gradient Composite Solid Electrolyte.

Solid-state batteries promise to meet the challenges of high energy density and high safety for future energy storage. However, poor interfacial contact and complex manufacturing processes limit their practical applications. Herein, a simple strategy is proposed to enhance interfacial contact by introducing a gradient composite polymer solid electrolyte (GCPE), which is prepared by a facile UV-curing polymerization technique.

Early Pleistocene hominin teeth from Meipu, southern China.

The rarity and poor preservation of hominin fossils from the East Asian Early Pleistocene hamper our understanding of their taxonomy and possible phylogenetic relationship with other members of the genus Homo. In the 1970s, four isolated hominin teeth were recovered from the Meipu site, southern China, which biostratigraphic analysis placed in the late Early Pleistocene. Early reports assigned the teeth to late Homo erectus.

Activity Prediction of Small Molecule Inhibitors for Antirheumatoid Arthritis Targets Based on Artificial Intelligence.

Rheumatoid arthritis (RA) is a chronic autoimmune disease, which is compared to "immortal cancer" in industry. Currently, SYK, BTK, and JAK are the three major targets of protein tyrosine kinase for this disease. According to existing research, marketed and research drugs for RA are mostly based on single target, which limits their efficacy.