Background: The metabolic flexibility of endothelial cells is linked to their phenotypic plasticity. Frataxin is critical in determining the iron metabolism and fate of endothelial cells. This study aimed to investigate frataxin-mediated metabolic remodeling during the endothelial-to-mesenchymal transition (EndoMT).
View Article and Find Full Text PDFBackground: Efferocytosis is an activity of macrophages that is pivotal for the resolution of inflammation in hypertension. The precise mechanism by which macrophages coordinate efferocytosis and internalize apoptotic cardiomyocytes remains unknown. The aim of this study was to determine whether SIRT3 (sirtuin-3) is required for both apoptotic cardiomyocyte engulfment and anti-inflammatory responses during efferocytosis.
View Article and Find Full Text PDFBackground: Cardiac fibroblasts (CFs) and cardiomyocytes are the major cell populations in the heart. CFs not only support cardiomyocytes by producing extracellular matrix (ECM) but also assimilate myocardial nutrient metabolism. Recent studies suggest that the classical intercellular lactate shuttle may function in the heart, with lactate transported from CFs to cardiomyocytes.
View Article and Find Full Text PDFRejuvenation Res
February 2022
Oxidative stress may be an important cause of erythrocyte senescence. Angiotensin II (Ang II) has recently been shown to promote vascular cell senescence. However, its effects on erythrocytes remain unclear.
View Article and Find Full Text PDFObjective: Infiltrated macrophages actively promote perivascular adipose tissue remodeling and represent a dominant population in the perivascular adipose tissue microenvironment of hypertensive mice. However, the role of macrophages in initiating metabolic inflammation remains uncertain. SIRT3 (sirtuin-3), a NAD-dependent deacetylase, is sensitive to metabolic status and mediates adaptation responses.
View Article and Find Full Text PDFThe impairment of autophagy can cause cellular metabolic perturbations involved in endothelial-to-mesenchymal transition (EndoMT). However, the interplay between the cellular autophagy machinery and endothelial metabolism remains elusive. Sirtuin 3 (SIRT3), an NAD-dependent deacetylase, is a major cellular sensor of energy metabolism.
View Article and Find Full Text PDFPrevious study indicated that Sirtuin 3 (SIRT3) is a central regulator of adaptive thermogenesis in brown adipose tissue (BAT). Here we investigate the role of SIRT3 in the modulation of cellular phenotype in BAT under high salt intake (HS). HS downregulated SIRT3 level in BAT, accompanied by decreased oxygen consumption rate, and caused a severe loss of BAT characteristics.
View Article and Find Full Text PDFJ Cardiovasc Pharmacol
May 2019
Nebivolol is a novel β-adrenergic receptor (β-AR) blocker with anti-inflammatory and antioxidant properties. The NLRP3 inflammasome plays a pivotal role in the pathogenesis of obesity-induced vascular dysfunction. Our study aimed to explore the effect of nebivolol on the NLRP3 inflammasome and vascular remodeling in diet-induced obese rats.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Basis Dis
March 2018
Defective autophagy of monocytes or macrophages might result in NLRP3 inflammasome activation and cause vascular metabolic inflammation. However, the mechanism underlying the initiation of the autophagy response to hyperlipidaemia remains unclear. Sirtuin 3 (SIRT3), an NAD-dependent deacetylase, is sensitive to the metabolic status and mediates adaptation responses.
View Article and Find Full Text PDFBackground: Emerging evidence indicates that impaired angiogenesis may contribute to hypertension-induced cardiac remodeling. The nicotinamide adenine dinucleotide-dependent deacetylase Sirtuin 3 (SIRT3) has the potential to modulate angiogenesis, but this has not been confirmed. As such, the aim of this study was to examine the relationship between SIRT3-mediated angiogenesis and cardiac remodeling.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Cell Biol Lipids
September 2017
Aims: To investigate whether haematopoietic TLR4 deletion attenuates perivascular brown adipose tissue inflammation in atherosclerotic mice.
Methods And Results: Experiments were performed using irradiated LDL receptor-deficient (LDLR) mice with marrow from either TLR4-deficient (TLR4) or age-matched wild-type (WT) mice. After 12 weeks of being fed a high-cholesterol diet, TLR4→LDLR mice developed fewer atherosclerotic lesions in the aorta compared to WT→LDLR mice.
NLRP3 is involved in obesity-induced cardiac remodeling and dysfunction. In this study, we evaluated whether the cardiac protective effects of nebivolol relied on attenuating NLRP3 activation in a juvenile-adolescent animal model of diet-induced obesity. Weaning male Sprague-Dawley rats were fed with either a standard chow diet (ND) or a high-fat diet (HFD) for 8 weeks.
View Article and Find Full Text PDFThe aim of this study was to determine the expression of B7-H3, B7-H4, Foxp3 and IL-2 in cervical cancer tissues, and evaluate the corresponding clinical significance. The expression of B7-H3, B7-H4, Foxp3 and IL-2 in 108 cervical cancer specimens was detected using immunohistochemistry, and their relationship with clinicopathologic parameters was determined. B7-H3, B7-H4 and Foxp3 had high levels of expression in cervical cancer cells (72.
View Article and Find Full Text PDFZhonghua Yi Xue Za Zhi
October 2015
Objective: To investigate the expression of death domain associated protein (Daxx) and human papillomavirus 16 E6 protein (HPV16 E6) in cervical lesions and analyze their significance.
Methods: Immunohistochemical SABC method was used to detect the expression of Daxx and HPV16 E6 in 194 cases of cervical tissues with different lesions.
Results: (1) The positive expression rate of Daxx was 28.
Sex-determining region Y-related high mobility group box 2 (SOX-2) is a key pluripotency-associated transcription factor and may be implicated in the pathogenesis of cervical squamous cell carcinoma (SCC). The aim of this study was to explore SOX-2 expression in cervical SCC tissues and to examine whether and how SOX-2 regulates the malignant behaviors of cervical SCC cells in vitro. We here found that SOX-2 expression in the examined cervical SCC tissues was higher than that in the normal cervical and cervical intraepithelial neoplasia (CIN) tissues.
View Article and Find Full Text PDFChemerin is a novel adipocyte-derived factor that induces insulin resistance in skeletal muscle. However, the effect of chemerin on skeletal muscle mitochondrial function has received little attention. In the present study, we investigated whether mitochondrial dysfunction is involved in the pathogenesis of chemerin-mediated insulin resistance.
View Article and Find Full Text PDFWe investigated the significance of high- mobility group box1 (HMGB1) and T-cell-mediated immunity and prognostic value in cervical cancer. HMGB1, forkhead/winged helix transcription factor p3 (Foxp3), IL-2, and IL-10 protein expression was analyzed in 100 cervical tissue samples including cervical cancer, cervical intraepithelial neoplasia (CIN), and healthy control samples using immunohistochemistry. Serum squamous cell carcinoma antigen (SCC-Ag) was immunoradiometrically measured in 32 serum samples from 37 cases of squamous cervical cancer.
View Article and Find Full Text PDFZhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
October 2013
Sapium sebiferum contains a variety of organic acids, flavonoids and phenolic substances, which were linked with the functions of poisoning Oncomelania. Sapium sebiferum is a good plant material of inhibiting Oncomelania. This paper reviews the variety, resources and active ingredients of Sapium sebiferum, and the researches of Sapium sebiferum inhibiting Oncomelania, and forecasts the development of Sapium sebiferum as an inhibiting Oncomelania forest in order to provide the evidence for its penetrating research and development.
View Article and Find Full Text PDFBiochem Biophys Res Commun
November 2013
Emerging evidence indicates exercise training could mediate mitochondrial quality control through the improvement of mitochondrial dynamics. Ginsenoside Rg3 (Rg3), one of the active ingredients in Panax ginseng, is well known in herbal medicine as a tonic and restorative agent. However, the molecular mechanism underlying the beneficial effects of Rg3 has been elusive.
View Article and Find Full Text PDFBiochem Biophys Res Commun
August 2013
Nebivolol is a third-generation β-adrenergic receptor (β-AR) blocker with additional beneficial effects, including the improvement of lipid and glucose metabolism in obese individuals. However, the underlying mechanism of nebivolol's role in regulating the lipid profile remains largely unknown. In this study, we investigated the role of nebivolol in mitochondrial biogenesis in 3T3-L1 adipocytes.
View Article and Find Full Text PDFZhonghua Xin Xue Guan Bing Za Zhi
June 2007
Objective: To investigate the association of MspI polymorphism of Cytochrome P4501A1 (CYP1A1) gene and smoking to the susceptibility to coronary artery disease (CAD).
Methods: The genotypes of CYP1A1 MspI site were detected using the methods of polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) in 349 cases with CAD and 404 non-CAD as controls. CAD diagnosis was confirmed by coronary angiograms.
Ying Yong Sheng Tai Xue Bao
May 2005
Based on the concentration analyses of S, Mn, Fe, Zn, Cu and Pb in the growth ring set of Pinus taiwanensis at the summit (1,400-1,600 m alt.) of Huangshan Mountains during past 80 years, this paper studied the dynamic characters of element concentrations in the ring set, and their relationships with atmospheric environment. The results showed that there were three levels of S concentration in the growth ring set, i.
View Article and Find Full Text PDFYing Yong Sheng Tai Xue Bao
November 2004
The study showed that under summer shade condition, the diurnal variation of net photosynthetic rate of Gynostemma pentaphyllum presented nontypical double apex, the first apex being 13.8 micromol CO2 x m(-2) x s(-1) at 11:00, and the diurnal net photosynthetic rate was about 176.97 micromol CO2 x m(-2), 3.
View Article and Find Full Text PDFYing Yong Sheng Tai Xue Bao
July 2004
Studies on the photosynthetic and respiratory rates, light utilization efficiencies and light compensations of five climbing plants showed that the diurnal variations of photosynthetic rates presented double peak, the first peak was between 10:00 to 12:00, and the second was between 14:00 to 16:00. The phenomenon of "noon break" was obvious. The diurnal variations of respiration rates also presented double peak, the first peak was between 11:00 to 13:00, and the second was between 14:00 to 17:00.
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