Metabolics-Based Study on the Therapeutic Mechanism Behind the Effect of Shenhuang Plaster Applied to the Shenque Acupoint on Gastrointestinal Motility in POI Mice.

Background: Postoperative ileus (POI) is a common postoperative clinical complication that significantly affects postoperative rehabilitation and quality of life in patients and can even produce secondary complications, leading to serious consequences. External treatment using Shenhuang Plaster (SHP) (Shenque acupoint administration) has definite effects and unique advantages in the prevention and treatment of POI, but its mechanism is not completely clear. In this study, we investigated the therapeutic mechanism behind the effect of Shenhuang Plaster applied to the Shenque acupoint on gastrointestinal motility in POI mice based on metabolomics.

USP38 Couples Histone Ubiquitination and Methylation via KDM5B to Resolve Inflammation.

Chromatin modifications, such as histone acetylation, ubiquitination, and methylation, play fundamental roles in maintaining chromatin architecture and regulating gene transcription. Although their crosstalk in chromatin remodeling has been gradually uncovered, the functional relationship between histone ubiquitination and methylation in regulating immunity and inflammation remains unclear. Here, it is reported that USP38 is a novel histone deubiquitinase that works together with the histone H3K4 modifier KDM5B to orchestrate inflammatory responses.

Interplay of mA and H3K27 trimethylation restrains inflammation during bacterial infection.

While -methyladenosine (mA) is the most prevalent modification of eukaryotic messenger RNA (mRNA) involved in various cellular responses, its role in modulating bacteria-induced inflammatory response remains elusive. Here, we showed that loss of the mA reader YTH-domain family 2 (YTHDF2) promoted demethylation of histone H3 lysine-27 trimethylation (H3K27me3), which led to enhanced production of proinflammatory cytokines and facilitated the deposition of mA cotranscriptionally. Mechanistically, the mRNA of lysine demethylase 6B () was mA-modified and its decay mediated by YTHDF2.

Adversarial Feature Alignment: Avoid Catastrophic Forgetting in Incremental Task Lifelong Learning.

Humans are able to master a variety of knowledge and skills with ongoing learning. By contrast, dramatic performance degradation is observed when new tasks are added to an existing neural network model. This phenomenon, termed , is one of the major roadblocks that prevent deep neural networks from achieving human-level artificial intelligence.

Prognostic and predictive value of a microRNA signature in adults with T-cell lymphoblastic lymphoma.

New prognostic factors are needed to establish indications for haematopoietic stem cell transplantation (HSCT) in first complete remission (CR1) for T-cell lymphoblastic lymphoma (T-LBL) patients. We used microarray to compare T-LBL tissue samples (n = 75) and fetal thymus tissues (n = 20), and identified 35 differentially expressed miRNAs. Using 107 subjects as the training group, we developed a five-miRNA-based classifier to predict patient survival with LASSO Cox regression: lower risk was associated with better prognosis (disease-free survival (DFS): hazard ratio (HR) 4.

Comparison of user satisfaction and image quality of fixed and mobile camera systems for 3-dimensional image capture of edentulous patients: A pilot clinical study.

Statement Of Problem: An evaluation of user satisfaction and image quality of a novel handheld purpose-built mobile camera system for 3-dimensional (3D) facial acquisition is lacking.

Purpose: The purpose of this pilot clinical study was to assess and compare the effectiveness between a handheld mobile camera system designed for facial acquisition and a fixed static camera arrangement by comparing the time effectiveness and the operator and participant preference for the 2 techniques of image capture.

Material And Methods: Completely edentulous participants (n=12: women=7, men=5; mean age: 74.

Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development.

TRIM family members have been implicated in a variety of biological processes such as differentiation and development. We here found that Trim59 plays a critical role in early embryo development from blastocyst stage to gastrula. There existed delayed development and empty yolk sacs from embryonic day (E) 8.

NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A.

The adaptor protein TRAF6 has a central function in Toll-like receptor (TLR) signalling, yet the molecular mechanisms controlling its activity and stability are unclear. Here we show that NLRP11, a primate specific gene, inhibits TLR signalling by targeting TRAF6 for degradation. NLRP11 recruits the ubiquitin ligase RNF19A to catalyze K48-linked ubiquitination of TRAF6 at multiple sites, thereby leading to the degradation of TRAF6.

NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis.

MAVS signalosome plays an important role in RIG-I-like receptor (RLR)-induced antiviral signaling. Upon the recognition of viral RNAs, RLRs activate MAVS, which further recruits TRAF6 and other signaling proteins to initiate type I interferon (IFN) activation. MAVS signalosome also regulates virus-induced apoptosis to limit viral replication.

LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex.

Activation of NF-κB signaling plays pivotal roles in innate immune responses against pathogens. It requires strict control to avert inflammatory diseases. However, the mechanisms underlying this tight regulation are not completely understood.

Fusing multiview and photometric stereo for 3D reconstruction under uncalibrated illumination.

We propose a method to obtain a complete and accurate 3D model from multiview images captured under a variety of unknown illuminations. Based on recent results showing that for Lambertian objects, general illumination can be approximated well using low-order spherical harmonics, we develop a robust alternating approach to recover surface normals. Surface normals are initialized using a multi-illumination multiview stereo algorithm, then refined using a robust alternating optimization method based on the l(1) metric.