Rnf40 Exacerbates Hypertension-Induced Cerebrovascular Endothelial Barrier Dysfunction by Ubiquitination and Degradation of Parkin.

Aims: We aimed to investigate the role of Rnf40 in hypertension-induced cerebrovascular endothelial barrier dysfunction and cognitive impairment.

Methods: We employed microarray data analysis and integrated bioinformatics databases to identify a novel E3 ligase, Rnf40, that targets Parkin. To understand the role of RNF40 in hypertension-induced cerebrovascular endothelial cell damage, we used pAAV-hFLT1-MCS-EGFP-3×Flag-mir30shRnf40 to establish an Rnf40-deficient model in spontaneously hypertensive rats (SHRs).

Dietary sodium/potassium intake and cognitive impairment in older patients with hypertension: Data from NHANES 2011-2014.

This study aimed to assess the relationship between dietary sodium/potassium intake and cognition in elderly individuals with hypertension. We designed a cross-sectional study based on the 2011-2014 National Health and Nutrition Examination Survey (NHANES) 2011-2014. A multivariable-logistic regression analysis was performed to analyze the relationship between sodium/potassium intake and cognitive impairment.

Effect of different treatments for obstructive sleep apnoea on blood pressure.

Objective: Obstructive sleep apnoea (OSA) is a common cause of secondary hypertension. This network meta-analysis (NMA) assessed the effect of different OSA treatments on lowering blood pressure.

Methods: PubMed, EMBASE, Web of Science, and Cochrane Library databases were searched for relevant randomized controlled trials.

PROGNOSTIC SIGNIFICANCE AND LIMITATION OF VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY IN PATIENTS WITH REDUCED EJECTION FRACTION: A MINI-REVIEW.

Visit-to-visit variability (VVV) of blood pressure (BP) can facilitate in predicting future reduced ejection fractions cases. In the recent past, the prognostic significance of visitto-visit variability of BP has been examined widely in patients with a high risk of cardiovascular disease. The findings of numerous investigations have indicated that increased visit-to-visit variability of blood pressure can lead to better estimation or proper treatments that can minimize blood pressure variability and associated risks while enhancing clinical outcomes.

Polymerase chain reaction combined with fluorescent lateral flow immunoassay based on magnetic purification for rapid detection of canine parvovirus 2.

Background: Canine parvovirus 2 (CPV-2) is one of the most common etiological agents that cause severe gastroenteritis in puppies. Early accurate diagnosis is important for infected dogs. In recent years, magnetic separation has become an efficient and useful tool for bioassays.

Survey of basic medical researchers on the awareness of animal experimental designs and reporting standards in China.

Objective: To investigate the awareness and use of the Systematic Review Center for Laboratory Animal Experimentation's (SYRCLE) risk-of-bias tool, the Animal Research: Reporting of In Vivo Experiments (ARRIVE) reporting guidelines, and Gold Standard Publication Checklist (GSPC) in China in basic medical researchers of animal experimental studies.

Methods: A national questionnaire-based survey targeting basic medical researchers was carried in China to investigate the basic information and awareness of SYRCLE's risk of bias tool, ARRIVE guidelines, GSPC, and animal experimental bias risk control factors. The EpiData3.