Fucoidan ameliorates rotenone-induced Parkinsonism in mice by regulating the microbiota-gut-brain axis.

Microbiota-gut-brain axis, the bidirectional relationship between the gut microbiota and the brain, has been increasingly appreciated in the pathogenesis of Parkinson's disease (PD). Fucoidan, a sulphate-rich polysaccharide, has been shown to be neuroprotective by reducing oxidative stress in PD models. However, the role of microbiota-gut-brain axis in the neuroprotective activity of fucoidan has not been revealed.

Reactive oxygen species-responsive polydopamine-PtCuTe nanoparticle-loaded microneedle system for promoting the healing of infected skin wounds.

Nanozymes, known for their high efficiency in scavenging reactive oxygen species (ROS), have received significant attention in promoting the healing of infected wounds. Herein, we reported a novel multifunctional PDA-PtCuTe nanozyme with excellent ROS scavenging, antibacterial, pro-angiogenic, anti-inflammatory, and immune regulatory properties. It was loaded onto microneedles (PTPP-MN) for treating infected wounds.

Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na-Ca transporter-mediated autophagy in alzheimer-like mice.

Introduction: Nav1.6 is closely related to the pathology of Alzheimer's Disease (AD), and astrocytes have recently been identified as a significant source of β-amyloid (Aβ). However, little is known about the connection between Nav1.

Natural Exponential and Three-Dimensional Chaotic System.

Existing chaotic system exhibits unpredictability and nonrepeatability in a deterministic nonlinear architecture, presented as a combination of definiteness and stochasticity. However, traditional two-dimensional chaotic systems cannot provide sufficient information in the dynamic motion and usually feature low sensitivity to initial system input, which makes them computationally prohibitive in accurate time series prediction and weak periodic component detection. Here, a natural exponential and three-dimensional chaotic system with higher sensitivity to initial system input conditions showing astonishing extensibility in time series prediction and image processing is proposed.

Single-View Measurement Method for Egg Size Based on Small-Batch Images.

Egg size is a crucial indicator for consumer evaluation and quality grading. The main goal of this study is to measure eggs' major and minor axes based on deep learning and single-view metrology. In this paper, we designed an egg-carrying component to obtain the actual outline of eggs.

Corrigendum: Field pest monitoring and forecasting system for pest control.

[This corrects the article DOI: 10.3389/fpls.2022.

Field pest monitoring and forecasting system for pest control.

Insect pest is an essential factor affecting crop yield, and the effect of pest control depends on the timeliness and accuracy of pest forecasting. The traditional method forecasts pest outbreaks by manually observing (capturing), identifying, and counting insects, which is very time-consuming and laborious. Therefore, developing a method that can more timely and accurately identify insects and obtain insect information.

Dietary diversity offsets the adverse mortality risk among older indigenous Taiwanese.

Background And Objectives: The extent to which health and survival inequality between indigenous and nonindigenous older Taiwanese is associated with diet is uncertain.

Methods And Study Design: Participants from the Elderly Nutrition and Health Survey in Taiwan (1999-2000) formed this cohort. Dietary information was collected by 24-hr recall and simplified food frequency questionnaire.

NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer.

Colorectal cancer (CRC) is a growing cause of mortality in developing countries, warranting investigation into its earlier detection for optimal disease management. A metabolomics based approach provides potential for noninvasive identification of biomarkers of colorectal carcinogenesis, as well as dissection of molecular pathways of pathophysiological conditions. Here, proton nuclear magnetic resonance spectroscopy (1HNMR) -based metabolomic approach was used to profile fecal metabolites of 68 CRC patients (stage I/II=20; stage III=25 and stage IV=23) and 32 healthy controls (HC).