Publications by authors named "Chengkai Yu"
Article Synopsis
- Foodborne pathogens present significant food safety issues, with a specific virulent bacterium causing major public health concerns.
- Traditional detection methods for this bacterium are often slow, labor-intensive, and require specialized equipment and trained personnel.
- The paper introduces a new detection platform using CRISPR/Cas12a, allowing for rapid, accurate, and visible identification of the pathogen, making it user-friendly and suitable for point-of-care testing in food safety.
Metabolic engineering of Lactococcus lactis for high level accumulation of glutathione and S-adenosyl-L-methionine.
World J Microbiol Biotechnol
November 2019
Glutathione (GSH) and S-adenosyl methionine (SAM) have been applied as liver-protective factors to prevent and treat many different liver damages and diseases. Due to their low stability and short half-life, oral administration of GSH or SAM might be replaced by continuous supplying through living lactic bacteria in yogurt. In this study, Lactococcus lactis was engineered via synthetic biology strategies to produce these two important molecules.
View Article and Find Full Text PDFBackground: Inactivated vaccines for hepatitis A virus (HAV) infection are widely used in China. Mass vaccination programs drive the need for data on long-term persistence of vaccine-induced protection.
Methods: A prospective, randomized, open-label clinical trial was conducted to compare geometric mean concentrations (GMCs) and seroconversion rates (SRs) of anti-HAV antibody elicited by the inactivated vaccines Healive and Havrix for 5 y post immunization, in which 400 healthy children were randomly assigned in a 3:1 ratio to receive 2 doses of Healive or Havrix at 0 and 6 month.