Publications by authors named "Chengju Hu"

We propose a novel, to our knowledge, resource allocation algorithm (RAA) for a multi-user non-orthogonal multiple access orthogonal frequency division multiplexing (NOMA-OFDM) visible light communication (VLC) system. The proposed algorithm considers both the interference between users and their channel diversity. Bit allocation to users in each iteration is based on the ratio between the already allocated number of bits and the demanded number of bits of users, rather than their channel gains.

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The study aimed to evaluate the interobserver agreement among glaucoma subspecialists in diagnosing glaucoma and to explore the causes of diagnostic discrepancies. Three experienced glaucoma subspecialists independently assessed frequency domain optical coherence tomography, fundus color photographs, and static perimetry results from 464 eyes of 275 participants, adhering to unified glaucoma diagnostic criteria. All data were collected from the Wenzhou Glaucoma Progression Study between August 2014 and June 2021.

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Background: Gastric cancer (GC) is one of the most common cancers worldwide. Tumor microenvironment plays an important role in tumor progression. This study aims to explore the role of cancer-associated fibroblasts (CAFs) in GC and the underlying mechanism.

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We propose a simple but high-performance trigonometric-memory-polynomial decision-feedback equalizer (TMP-DFE) to cope with the nonlinear distortions in intensity-modulation direct-detection (IM/DD) systems. The proposed method employs sine and cosine operations of received samples, which can be implemented by the efficient CORDIC algorithm using only additions and shifts, to fit odd- and even-order nonlinearities with the effect of different nonlinear orders adjusted by the nonlinear factor. We further propose TMP improved-weighted DFE (TMP-IWDFE) to reduce the error propagation probability of decision feedback.

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Purpose: To explore the association between progressive peripapillary capillary vessel density (pcVD) reduction and the progression of visual field (VF) impairment in individuals with normal tension glaucoma (NTG).

Design: Prospective cohort study.

Methods: The study enrolled 110 participants with one eye each, totalling 110 NTG eyes.

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Signal readout technologies that do not require any instrument are essential for improving the convenience and availability of paper-based sensors. Thanks to the remarkable progress in material science and nanotechnology, paper-based sensors with instrument-free signal readout have been developed for multiple purposes, such as biomedical detection, environmental pollutant tracking, and food analysis. In this review, the developments in instrument-free signal readout technologies for paper-based sensors from 2020 to 2023 are summarized.

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Objective: Excessive obesity can lead to dysfunction in adipose tissue, which contributes to the development of comorbidities associated with obesity, such as type 2 diabetes (T2D), cardiovascular and cerebrovascular disease, among others. Previous research has mainly focused on the Vanin family in systemic inflammatory diseases or predicting its role in tumor prognosis, while neglecting its role as a secretory protein in adipose tissue inflammation and metabolism. The objective of this study was to compare the changes in Vanin-2 levels in the circulating blood of normal and obese individuals, and to assess its correlation with inflammatory factors .

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Purpose: To investigate whether quantitative optical coherence tomography angiography (OCTA) metrics of the superficial/deep macular retina are associated with the development of visual field (VF) loss in the fellow eyes of normal tension glaucoma (NTG) patients with unilateral VF loss.

Methods: A longitudinal study was conducted in which 61 eyes with normal VF (mean VF mean deviation -0.7±1.

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Purpose: The aim of the study was to characterize and compare the longitudinal changes of macular vessel density (VD) in primary open angle glaucoma (POAG) eyes across different disease stages.

Methods: This is a sub-analysis of a prospective cohort study. A total of 103 eyes (53 eyes in the mild stage, 50 eyes in the moderate-to-advanced stage) of 75 POAG patients followed for more than 1 year with at least 2 qualified optical coherence tomography (OCT) angiography (OCTA) images were included.

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Synopsis of recent research by authors named "Chengju Hu"

  • - Chengju Hu's recent research focuses on the intersection of cancer biology, ocular health, and innovative sensor technology, with significant contributions to understanding cancer-associated fibroblasts in gastric cancer and visual field impairment in glaucoma.
  • - One notable finding relates to how WNT5A from cancer-associated fibroblasts promotes various malignant behaviors in gastric cancer, including increased cell proliferation and glycolysis, which highlights the tumor microenvironment's role in cancer progression.
  • - Additionally, Hu's studies on normal tension glaucoma reveal critical associations between capillary density loss and visual field progression, suggesting potential biomarkers for monitoring disease severity, alongside advancements in paper-based sensor technologies for diverse applications.