The assistive role of an internal fluid circulatory device in ureteroscopic lithotripsy: a randomized, controlled and prospective study.

Purpose: To evaluate and compare the efficacy of a newly designed in-house assistive internal fluid circulatory device in ureteroscopic lithotripsy for ureteral stones.

Methods: In this study, 97 patients were assigned to the trial group and underwent ureteroscopic lithotripsy with an in-house newly designed assistive internal fluid circulatory device; 96 patients were assigned to the control group and underwent traditional ureteroscopic lithotripsy without the assistive device. The primary outcome was the final stone-free rate (SFR) at 1-month post-surgery.

Sandwich-structured FeO@C@MoSe architecture for efficient lithium-ion storage.

A unique sandwich structure FeO@C@MoSe architecture is proposed for high-performance lithium storage. Carbon shell as the connection of in/external structures can not only improve the overall conductivity but also alleviate the volume expansion of FeO and avoid the aggregation of MoSe nanosheets. Moreover, MoSe nanosheets on carbon shell demonstrate enlarged interlayer spacing, which can accelerate the kinetics of Li, and thus improve the rate performance.

Controlling the Selectivity of Reaction Products by Transmetalation on a Ag(111) Substrate.

On-surface synthesis has shown great promise in the precise bottom-up preparation of molecular nanostructures. Apart from the direct C-C coupling reaction pathway, an alternative strategy is to exploit the metal-organic interactions provided by integrated metals for preassembly, which exhibit high reversibility and can anchor specific conformations of molecular precursors, thus allowing the precise construction of nanostructures with improved reaction selectivity. Previous studies have mainly been devoted to the construction of target reaction products through the incorporation of metal atoms, ranging from intrinsic to extrinsic atoms on metal substrates and, more recently, to their cooperative effects.

The effect of rumination on problematic mobile phone use among female freshmen: A moderated mediation model.

Based on the Interaction of Person-Affect-Cognition-Execution model and the risk-buffering model, the current study explored how and when rumination increases problematic mobile phone use (PMPU) among Chinese female freshmen. Specifically, we investigated the underlying mechanism of PMPU by testing a moderated mediation model in which solitude capacity moderated the mediating role of fear of missing out (FoMO) in the relationship between rumination and PMPU. A sample of 1,389 female freshmen in China, with a mean age of 19.

The Technology to Enhance Patient Motivation in Virtual Reality Rehabilitation: A Review.

Virtual reality (VR) technology has experienced a steady rise and has been widely applied in the field of rehabilitation. The integration of VR technology in rehabilitation has shown promising results in enhancing their motivation for treatment, thereby enabling patients to actively engage in rehab training. Despite the advancement, there is a dearth of comprehensive summary and analysis on the use of VR technology to enhance patient motivation in rehabilitation.

Analyzing Quantum Entanglement with the Schmidt Decomposition in Operator Space.

Characterizing entanglement is central for quantum information science. Special observables which indicate entanglement, so-called entanglement witnesses, are a widely used tool for this task. The construction of these witnesses typically relies on the observation that quantum states with a high fidelity to some entangled target state are entangled, too.

Stabilized, ROS-sensitive β-cyclodextrin-grafted hyaluronic supramolecular nanocontainers for CD44-targeted anticancer drug delivery.

Hyaluronic acid (HA)-based tumor microenvironment-responsive nanocontainers are attractive candidates for anticancer drug delivery due to HA's excellent biocompatibility, biodegradability, and CD44-targeting properties. Nevertheless, the consecutive synthesis of stabilized, stealthy, responsive HA-based multicomponent nanomedicines generally requires multi-step preparation and purification procedures, leading to batch-to-batch variation and scale-up difficulties. To develop a facile yet robust strategy for promoted translations, a silica monomer containing a cross-linkable diethoxysilyl unit was prepared to enable in situ crosslinking without any additives.

CFI: a VR motor rehabilitation serious game design framework integrating rehabilitation function and game design principles with an upper limb case.

Virtual reality (VR) Rehabilitation holds the potential to address the challenge that patients feel bored and give up long-term rehabilitation training. Despite the introduction of gaming elements by some researchers in rehabilitation training to enhance engagement, there remains a notable lack of in-depth research on VR rehabilitation serious game design methods, particularly the absence of a concrete design framework for VR rehabilitation serious games. Hence, we introduce the Clinical-Function-Interesting (CFI): a VR rehabilitation serious game design framework, harmonizing rehabilitation function and game design theories.

Toward Heisenberg scaling in non-Hermitian metrology at the quantum regime.

Non-Hermitian quantum metrology, an emerging field at the intersection of quantum estimation and non-Hermitian physics, holds promise for revolutionizing precision measurement. Here, we present a comprehensive investigation of non-Hermitian quantum parameter estimation in the quantum regime, with a special focus on achieving Heisenberg scaling. We introduce a concise expression for the quantum Fisher information (QFI) that applies to general non-Hermitian Hamiltonians, enabling the analysis of estimation precision in these systems.

Transcriptome Analysis Reveals Dynamic Microglial-Induced A1 Astrocyte Reactivity via C3/C3aR/NF-κB Signaling After Ischemic Stroke.

Microglia and astrocytes are key players in neuroinflammation and ischemic stroke. A1 astrocytes are a subtype of astrocytes that are extremely neurotoxic and quickly kill neurons. Although the detrimental A1 astrocytes are present in many neurodegenerative diseases and are considered to accelerate neurodegeneration, their role in the pathophysiology of ischemic stroke is poorly understood.

Matrin-3 acts as a potential biomarker and promotes hepatocellular carcinoma progression by interacting with cell cycle-regulating genes.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The oncogenic role of Matrin-3 (MATR3), an a nuclear matrix protein, in HCC remains largely unknown. Here, we document the biological function of MATR3 in HCC based on integrated bioinformatics analysis and functional studies.

Neural Correlation of EEG and Eye Movement in Natural Grasping Intention Estimation.

Decoding the user's natural grasp intent enhances the application of wearable robots, improving the daily lives of individuals with disabilities. Electroencephalogram (EEG) and eye movements are two natural representations when users generate grasp intent in their minds, with current studies decoding human intent by fusing EEG and eye movement signals. However, the neural correlation between these two signals remains unclear.

A precise method to monitor hydroxyl radical in natural waters based on a fluoride-containing fluorescence probe.

In natural waters, hydroxyl radical (OH) can initiate many free radical-induced reactions, oxidizing various inorganic and organic compounds through electron transfer reactions, dehydrogenation reactions, addition reactions, and self-quenching reactions. However, due to its extremely low concentration and short lifetime in natural waters, studies on the quantitative measurement of OH levels are insufficient. In this work, we developed the first quinolinium-based fluorescence probe containing fluoride substituted donor that could detect hydroxyl radicals in the water system.

Irregular sleep and cardiometabolic risk: Clinical evidence and mechanisms.

Sleep regularity is an essential part of the multidimensional sleep health framework. The phenomenon of irregular sleep patterns is widespread in contemporary lifestyles. This review synthesizes clinical evidence to summarize the measures of sleep regularity and discusses the role of different sleep regularity indicators in developing cardiometabolic diseases (coronary heart disease, hypertension, obesity, and diabetes).

TCRαβNK1.1CD4CD8 double-negative T cells inhibit central and peripheral inflammation and ameliorate ischemic stroke in mice.

Excessive immune activation leads to secondary injury and impedes injured brain recovery after ischemic stroke. However, few effective methods are currently used for equilibrating immune balance. CD3NK1.

Diversification of phenolic glucosides by two UDP-glucosyltransferases featuring complementary regioselectivity.

Background: Glucoside natural products have been showing great medicinal values and potentials. However, the production of glucosides by plant extraction, chemical synthesis, and traditional biotransformation is insufficient to meet the fast-growing pharmaceutical demands. Microbial synthetic biology offers promising strategies for synthesis and diversification of plant glycosides.

Experimental Investigation of Quantum Correlations in a Two-Qutrit Spin System.

We report an experimental investigation of quantum correlations in a two-qutrit spin system in a single nitrogen-vacancy center in diamond at room temperatures. Quantum entanglement between two qutrits was observed at room temperature, and the existence of nonclassical correlations beyond entanglement in the qutrit case has been revealed. Our work demonstrates the potential of the NV centers as the multiqutrit system to execute quantum information tasks and provides a powerful experimental platform for studying the fundamental physics of high-dimensional quantum systems in the future.

Eagle Syndrome with Internal Carotid Artery Compression Causing Recurred Syncope.

We herein report a 54-year-old man with eagle syndrome who presented with repeated episodes of syncope, especially after moving his head to a downward position. Computed tomography with contrast revealed a bilateral elongated styloid process. The left internal carotid artery was obviously compressed by the left elongated styloid processes.

TTYH3, a potential prognosis biomarker associated with immune infiltration and immunotherapy response in lung cancer.

Purpose: The recognition of new diagnostic and prognostic biological markers for lung cancer is an essential and eager study. It's shown that ion channels play important roles in regulating various cellular processes and have been suggested to be associated with patient survival. However, tweety family member 3 (TTYH3), as a maxi-Cl channel, its role in lung cancer remains elusive.

Insulin receptor substrate 1(IRS1) is related with lymph node metastases and prognosis in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer-related mortality globally with a high risk of lymph node metastasis (LNM). In this study, weighted gene co-expression network analysis (WGCNA) showed the identification of 10 modules among which the significant module (turquoise), including 1352 genes, was correlated with LNM. A group 52 overlapping differentially expressed genes (DEGs) was identified based on the comparison of turquoise module with GSE23400 and GSE20347 datasets.

Study on the Safety of the New Radial Artery Hemostasis Device.

Objective: At present, the use of particular radial hemostatic devices after coronary angiography (CAG) or percutaneous coronary intervention (PCI) has become the primary method of hemostasis. Most control studies are based on the products already on the market, while only a few studies are on the new hemostatic devices. The aim of this study is to compare a new radial artery hemostasis device which is transformed based on the invention patent (Application number: CN201510275446) with TR Band (Terumo Medical) to evaluate its clinical effects.

Inhibition of Perforin-Mediated Neurotoxicity Attenuates Neurological Deficits After Ischemic Stroke.

Perforin-mediated cytotoxicity plays a crucial role in microbial defense, tumor surveillance, and primary autoimmune disorders. However, the contribution of the cytolytic protein perforin to ischemia-induced secondary tissue damage in the brain has not been fully investigated. Here, we examined the kinetics and subpopulations of perforin-positive cells and then evaluated the direct effects of perforin-mediated cytotoxicity on outcomes after ischemic stroke.

High resolution mapping of nighttime light and air pollutants during the COVID-19 lockdown in Wuhan.

Unlabelled: The novel coronavirus (COVID-19) has induced unprecedented improvements of air quality due to drastic shrinking of human activities during the pandemic lockdown in 2020. While declines of most air pollutants have been globally evidenced in most cities worldwide, there is few detailed spatial knowledge at local scale. Therefore, we present here a high resolution mapping of the 2018-2020 evolution of human activities and air pollutants in Wuhan.

Effects of poor plumage conditions on egg production, antioxidant status and gene expression in laying hens.

The objective of this study was to investigate the effects of poor plumage conditions on production performance, antioxidant status and gene expression in laying hens. Two hundred ten 54-week-old laying hens with similar body weights were assigned into two groups based on plumage conditions (the poor plumage conditions (PPC) group and the control group). All the birds had free access to water and crumbled feed, and received the same management in step cages.