Dynamic event-triggered quantized secure output consensus of heterogeneous multi-agent systems under DoS attacks.

This paper investigates secure output consensus problem of heterogeneous multi-agent systems (HMASs) under denial-of-service (DoS) attacks. First, an adaptive dynamic compensator depending on local measurement information is designed for tracking the signal of the virtual exosystem. Second, for mitigating network communication load, a novel adaptive control protocol is developed by introducing dynamic event-triggered control and quantized control strategies.

Computational identification and analysis of CNP0269688 as a natural product inhibitor disrupting the interaction between the HIV matrix domain and tRNA.

Our research is dedicated to combating HIV by targeting its Matrix (MA) domain, which is crucial for viral assembly and replication. This strategy specifically aims to interrupt early-stage infection and deter drug resistance by focusing on this essential domain. Due to the MA domain's conservation across different HIV strains, our approach promises broad-spectrum efficacy, which is particularly crucial in regions marked by significant genetic diversity and resistance issues.

Discovery of an 8-oxoguanine regulator PCBP1 inhibitor by virtual screening and its synergistic effects with ROS-modulating agents in pancreatic cancer.

Drugs that target reactive oxygen species (ROS) metabolism have progressed the treatment of pancreatic cancer treatment, yet their efficacy remains poor because of the adaptation of cancer cells to high concentration of ROS. Cells cope with ROS by recognizing 8-oxoguanine residues and processing severely oxidized RNA, which make it feasible to improve the efficacy of ROS-modulating drugs in pancreatic cancer by targeting 8-oxoguanine regulators. Poly(rC)-binding protein 1 (PCBP1) was identified as a potential oncogene in pancreatic cancer through datasets of The Cancer Genome Atlas (TCGA) project and Gene Expression Omnibus (GEO).

Serum biomarkers for predicting microvascular complications of diabetes mellitus.

Introduction: Diabetic microvascular complications such as retinopathy, nephropathy, and neuropathy are primary causes of blindness, terminal renal failure, and neuropathic disorders in type 2 diabetes mellitus patients. Identifying reliable biomarkers promptly is pivotal for early detection and intervention in these severe complications.

Areas Covered: This review offers a thorough examination of the latest research concerning serum biomarkers for the prediction and assessment of diabetic microvascular complications.

Fisetin disrupts mitochondrial homeostasis via superoxide dismutase 2 acetylation in pancreatic adenocarcinoma.

Pancreatic adenocarcinoma (PDAC) is one of the most lethal malignant tumors with an urgent need for precision medicine strategies. The present study seeks to assess the antitumor effects of fisetin, and characterize its impact on PDAC. Multi-omic approaches include proteomic, transcriptomic, and metabolomic analyses.

Synthesis of core-shell silicon-carbon nanocomposites via in-situ molten salt-based reduction of rice husks: A promising approach for the manufacture of lithium-ion battery anodes.

Silicon (Si) has gained substantial interest as a potential component of lithium-ion battery (LIB) anodes due to its high theoretical specific capacity. However, conventional methods for producing Si for anodes involve expensive metal reductants and stringent reducing environments. This paper describes the development of a calcium hydride (CaH)-aluminum chloride (AlCl) reduction system that was used for the in-situ low-temperature synthesis of a core-shell structured silicon-carbon (Si-C) material from rice husks (RHs), and the material was denoted RHs-Si@C.

Syntactic Errors in Older Adults with Depression.

: This study investigated the differences in syntactic errors in older individuals with and without major depressive disorder and cognitive function disparities between groups. We also explored the correlation between syntax scores and depression severity. : Forty-four participants, assessed for dementia with the Mini-Cog, completed the 15-item Geriatric Depression Scale (TGDS-15) and specific language tests.

Post-translational modification of CDK1-STAT3 signaling by fisetin suppresses pancreatic cancer stem cell properties.

Background: Pancreatic cancer stem cells (CSCs) promote pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and chemoresistance. Cyclin-dependent kinase 1 (CDK1) plays an important role in tumor initiation in other tumors, but the function of CDK1 in PDAC remains unclear. Fisetin is a bioactive flavonoid with anti-tumor properties in multiple tumors, while its function in CSCs remains elusive.

A pan-cancer analysis reveals the diagnostic and prognostic role of CDCA2 in low-grade glioma.

Background: Cell division cycle associated 2 (CDCA2), a member of the cell division cycle associated proteins (CDCA) family, is crucial in the regulation of cell mitosis and DNA repair. CDCA2 was extensively examined in our work to determine its role in a wide range of cancers.

Methods: CDCA2 differential expression was studied in pan-cancer and in diverse molecular and immunological subgroups in this research.

Sirtuin4 impacts mitochondrial homeostasis in pancreatic cancer cells by reducing the stability of AlkB homolog 1 via deacetylation of the HRD1-SEL1L complex.

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a poor prognosis. As a tumor inhibitor, the specific tumor suppressor mechanism of Sirtuin4(SIRT4) in PDAC remains elusive. In this study, SIRT4 was found to inhibit PDAC by impacting mitochondrial homeostasis.

Comparison of the left and right ventricular size and systolic function of low-risk fetuses in the third trimester: Which is more dominant?

Objective: To quantify fetal cardiovascular parameters utilizing fetal-specific 2D speckle tracking technique and to explore the differences in size and systolic function of the left and right ventricles in low-risk pregnancy.

Methods: A prospective cohort study was performed in 453 low-risk single fetuses (28-39 weeks) to evaluate ventricular size [i.e.

H-pyrophosphatases enhance low nitrogen stress tolerance in transgenic and wheat by interacting with a receptor-like protein kinase.

Introduction: Nitrogen is a major abiotic stress that affects plant productivity. Previous studies have shown that plant H+-pyrophosphatases (H+-PPases) enhance plant resistance to low nitrogen stress. However, the molecular mechanism underlying H+-PPase-mediated regulation of plant responses to low nitrogen stress is still unknown.

Nanostructured MoS with Interlayer Controllably Regulated by Ionic Liquids/Cellulose for High-Capacity and Durable Sodium Storage Properties.

Low intrinsic conductivity and structural instability of MoS as an anode of sodium-ion batteries limit the liberation of its theoretical capacity. Herein, density functional theory simulations for the first time optimize MoS interlayer distance between 0.80 and 1.

Genome-wide association study of agronomic traits related to nitrogen use efficiency in wheat.

GWAS identified 347 QTLs associated with eight traits related to nitrogen use efficiency in a 389-count wheat panel. Four novel candidate transcription factor genes were verified using qRT-PCR. Nitrogen is an essential nutrient for plants that determines crop yield.

Multifunctional on-chip directional coupler for spectral and polarimetric routing of Bloch surface wave.

Integration of multiple diversified functionalities into an ultracompact platform is crucial for the development of on-chip photonic devices. Recently, a promising all-dielectric two-dimensional platform based on Bloch surface waves (BSWs) sustained by dielectric multilayer has been proposed to enable various functionalities and provide novel approach to photonic devices. Here, we design and fabricate a multifunctional directional coupler to achieve both spectral and polarimetric routing by employing asymmetric nanoslits in a dielectric multilayer platform.

Observer-Based Dynamic Event-Triggered Semiglobal Bipartite Consensus of Linear Multi-Agent Systems With Input Saturation.

Observer-based dynamic event-triggered semiglobal bipartite consensus (SGBC) is investigated for linear multi-agent systems (MASs) with input saturation under a competitive network. Based on the estimated relative information and low-gain feedback technology, distributed dynamic event-triggered control (DETC) protocols are proposed for solving the observer-based SGBC problems for MASs under a fixed topology and a jointly connected topology, respectively. It is turned out that the SGBC of MASs can be achieved under the proposed protocols.

The interactions of CAP and LYN with the insulin signaling transducer CBL play an important role in polycystic ovary syndrome.

Background: Polycystic ovary syndrome (PCOS) is a hormonal disorder characterized by hyperandrogenism, ovulatory dysfunction, and insulin resistance. Evidence suggests that aberrations in insulin signaling-associated pathways may underlie PCOS pathogenesis. Our aim was to investigate the molecular mechanisms underlying PCOS and associated insulin resistance using in silico analyses, in vitro cell models, and in vivo murine models.

from Foxtail Millet () Confers Transgenic Rice Tolerance to High Salt Stress in the Field.

Salt stress is a major threat to crop quality and yield. Most experiments on salt stress-related genes have been conducted at the laboratory or greenhouse scale. Consequently, there is a lack of research demonstrating the merit of exploring these genes in field crops.

Transcriptome Differences in Response Mechanisms to Low-Nitrogen Stress in Two Wheat Varieties.

Nitrogen plays a crucial role in wheat growth and development. Here, we analyzed the tolerance of wheat strains XM26 and LM23 to low-nitrogen stress using a chlorate sensitivity experiment. Subsequently, we performed transcriptome analyses of both varieties exposed to low-nitrogen (LN) and normal (CK) treatments.

Impact of epidural labor analgesia using sufentanil combined with low-concentration ropivacaine on maternal and neonatal outcomes: a retrospective cohort study.

Background: Whether epidural administered sufentanil combined with low-concentration ropivacaine affected labor progress as well as maternal and neonatal outcomes still remained unknown. The aim of this study was to assess the impact of epidural sufentanil plus ropivacaine on maternal and neonatal outcomes.

Methods: This is a retrospective cohort study.

FGF21 Serum Levels in the Early Second Trimester Are Positively Correlated With the Risk of Subsequent Gestational Diabetes Mellitus: A Propensity-Matched Nested Case-Control Study.

Background: As an important endocrine hormone regulating glucose metabolism, fibroblast growth factor 21 (FGF21) is increased in individuals with gestational diabetes mellitus (GDM) after 24 gestational weeks. However, it is unknown whether the increase in FGF21 precedes the diagnosis of GDM.

Methods: In this nested case-control study, 133 pregnant women with GDM and 133 pregnant women with normal glucose tolerance (NGT) were identified through propensity score matching, and serum FGF21 levels were measured at 14 to 21 gestational weeks, before GDM is routinely identified.

Heterogeneous deniable authenticated encryption for location-based services.

The location-based services can provide users with the requested location information. But users also need to disclose their current location to the location-based service provider. Therefore, how to protect user's location privacy is a major concern.