Publications by authors named "Chengjie Xi"
Article Synopsis
- Myofiber size is important for overall health and can be influenced by factors like disease and aging.
- MuSK (muscle-specific kinase) plays a key role in the signaling process that affects muscle development, especially at neuromuscular junctions.
- Mice studies show that the absence of the MuSK Ig3 domain leads to smaller myofibers in slow muscles, while the mechanism involving the IGF1-Akt-mTOR pathway could be targeted for muscle growth and preventing muscle loss.
Intercellular communication between vascular and nerve cells mediated by diffusible proteins has recently emerged as a critical intrinsic program for neural development. However, whether the vascular smooth muscle cell (VSMC) secretome regulates the connectivity of neural circuits remains unknown. Here, we show that conditioned medium from brain VSMC cultures enhances multiple neuronal functions, such as neuritogenesis, neuronal maturation, and survival, thereby improving circuit connectivity.
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