Spherical cluster heterojunction engineering of NiFeP/g-CN for efficient oxygen evolution reaction in alkaline solution.

The construction of heterojunctions can reduce the energy barrier for the oxygen evolution reaction (OER), which is crucial for the design of efficient electrocatalysts. A novel OER electrocatalyst, composed of g-CN-supported NiFeP spherical nanoclusters, was successfully synthesized using a simple hydrothermal method and a gas-phase precipitation method. Benefiting from its unique spherical nanocluster structure and strong electronic interactions among Ni, Fe, and P, the catalyst exhibited outstanding performance under alkaline conditions, with an overpotential of only 232 mV at a current density of 10 mA cm and a Tafel slope of 103 mV dec.

A Layered Aluminophosphate [CHN][Al(PO)]·5HO with Fluorescent Property Derived from Carbazolyl-Modified Template.

Designing and innovating organic structure-directing agents is the key to synthesizing novel molecular sieve structures. Herein, we design a novel carbazolyl-modified template and further synthesize a two-dimensional layered aluminophosphate with [CHN][Al(PO)]·5HO (denoted as ZHKU-2). ZHKU-2 is composed of AA-stacked [AlPO16] layers constructed from alternating AlO and PO(=O) tetrahedrons to form a 4.

Performance and Mechanism of Chlorine Dioxide on BTEX Removal in Liquid and Indoor Air.

With the development of the chemical industry, benzene, toluene, ethylbenzene, and xylene (BTEX) have gradually become the major indoor air pollutants. Various gas treatment techniques are widely used to prevent the physical and mental health hazards of BTEX in semi-enclosed spaces. Chlorine dioxide (ClO) is an alternative to chlorine as a secondary disinfectant with a strong oxidation ability, a wide range of action, and no carcinogenic effects.

Experimental and Numerical Investigation of 3D Printing PLA Origami Tubes under Quasi-Static Uniaxial Compression.

The investigation aims to study the effects of temperature and damage constitutive model on the energy absorption performance of polymeric origami tubes under quasi-static impact. The uniaxial tensile responses of 3D-printed polylactic acid (PLA) samples following standard ASTM-D412 have been studied to characterize the mechanical properties at three temperatures: 30 °C, 40 °C, and 50 °C. The damage constitutive model is used to accurately characterize the stress-strain relations of the PLA.

Removing the sporoderm from the sporoderm-broken spores of improves the anticancer and immune-regulatory activity of water-soluble polysaccharide.

Plant-derived polysaccharides have demonstrated promising anti-cancer effects immune-regulatory activity. The aim of the current study was to compare the chemical property and the anticancer effects of polysaccharides extracted from the sporoderm-removed spores of the medicinal mushroom (RSGLP), which removed the sporoderm completely, with polysaccharides extracted from the sporoderm-broken spores of (BSGLP). We found that RSGLP has a higher extraction yield than BSGLP.

Influence of Loading Rate and Temperature on the Energy Absorption of 3D-Printed Polymeric Origami Tubes under Quasi-Static Loading.

Owing to deformation in the form of the diamond mode with high-energy absorption capacity, origami thin-walled tubes have attracted considerable attention in recent years. Stamping and welding are mainly employed to produce different types of origami thin-walled tubes. The processing defects and geometric asymmetry may be caused by the manufacturing process, which changes the collapsed mode and decreases the energy-absorbing capacity.

A novel electrochemical immunosensor based on PdAgPt/MoS for the ultrasensitive detection of CA 242.

Dynamic monitoring of tumor markers is an important way to the diagnosis of malignant tumor, evaluate the therapeutic effect of tumor and analyze the prognosis of cancer patients. As a tumor marker of digestive tract, CA242 is often used to Assess the therapeutic effect of colorectal cancer and pancreatic cancer. In this study, immunosensor technology was used to detect CA242.

A Mononuclear Iron(II) Spin-Crossover Molecule Decorated by Photochromic Azobenzene Group.

Aiming at constructing photoresponsive spin crossover (SCO) behavior, herein we designed a new ligand Abtz (Abtz = ()--(4-(()-phenyldiazenyl)phenyl)-1-(thiazol-4-yl)methanimine) which was decorated by a photochromic azobenzene group. Based on this photochromic ligand, a mononuclear Fe(II) SCO molecule [Fe(Abtz)](BF)·(EAC) (, EAC = ethyl acetate) was successfully synthesized and showed a complete one-step SCO behavior. Under continuous UV light and blue-light exposure, the photoisomerization of both ligand Abtz and compound in the liquid phase was confirmed through UV-Vis spectra.

A Label-Free Electrochemical Immunosensor for CEA Detection on a Novel Signal Amplification Platform of CuS/Pd/CuO Nanocomposites.

Carcinoembryonic antigen (CEA) is regarded as one of the crucial tumor markers for colorectal cancer. In this study, we developed the snowflake CuS/Pd/CuO nanocomposite to construct an original label-free electrochemical immunosensor for the ultrasensitive detection of CEA levels. The nanocomposite of cuprous sulfide (CuS) with Pd nanoparticles (Pd NPs) was synthesized through an formation of Pd NPs on the CuS.

Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon.

This study investigated the effects of water-soluble polysaccharide extracted from the sporoderm-removed spores of Ganoderma lucidum (GLP) against AOM/DSS-induced inflammation, tumorigenesis, and gut microbiota modification, which has never been reported before. Our data revealed that GLP (200 and 300 mg/kg) decreased AOM/DSS-induced colitis and tumorigenesis, manifested by significantly reduced disease activity index score, and total number and size of tumors. Furthermore, GLP ameliorated AOM/DSS-induced microbiota dysbiosis, increased short-chain fatty acid production, and alleviated endotoxemia by inhibiting TLR4/MyD88/NF-κB signaling.

Similarity Evaluation on the Compound TCM Formulation "Huoling Shengji Granule" and Its Placebo by Intelligent Sensory Evaluation Technologies and the Human Sensory Evaluation Method Based on Critical Quality Attributes.

To evaluate the similarity of Huoling Shengji granule (HLG) and its placebo at both granules and solution status, the innovative methods that consist of intelligent sensory evaluation technologies and human sensory evaluation methods were developed based on critical quality attributes (CQAs) of granule. The CQAs for traditional Chinese medicine (TCM) placebo granule were mainly divided into three categories: formulation attributes, visual attributes, and attributes of taste and smell. In this investigation, the novel intelligent sensory evaluation technologies including the physical property testing apparatus, computer vision system, color card, and electronic tongue (E-tongue) were employed for characterization of CQAs of HLG and its placebo.

Polysaccharides from sporoderm-removed spores of induce apoptosis in human gastric cancer cells via disruption of autophagic flux.

The sporoderm-broken spores of () polysaccharide (BSGLP) have been demonstrated to inhibit carcinogenesis in several types of cancer. However, to the best of our knowledge, the anticancer effects of polysaccharides extracted from the newly developed sporoderm-removed spores of (RSGLP) have not been assessed. The present study first compared the anticancer effects of RSGLP and BSGLP in three gastric cancer cell lines and it was found that RSGLP was more potent than BSGLP in decreasing gastric cancer cell viability.

Qizhen capsule inhibits colorectal cancer by inducing NAG-1/GDF15 expression that mediated via MAPK/ERK activation.

Ethnopharmacological Relevance: Qizhen capsule (QZC) is a traditional Chinese medicine (TCM) preparation that has been widely used in clinical practice and exerts promising therapeutic effects against breast, lung, and gastric cancers. However, studies have not reported whether QZC inhibits colorectal cancer (CRC) development and progression. Meanwhile, the underlying molecular mechanisms of its anticancer activity have not been studied.

Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation.

Ganoderma lucidum has been shown to have anti-obesity effects. However, polysaccharide extracted from the sporoderm-broken spores of Ganoderma lucidum (BSGLP) against obesity and its underlying mechanisms have never been reported. In the current study, we showed that BSGLP inhibited high-fat diet (HFD)-induced obesity, hyperlipidemia, inflammation, and fat accumulation in C57BL/6 J mice.

Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation.

Targeting autophagy may serve as a promising strategy for cancer therapy. Ganoderma lucidum polysaccharide (GLP) has been shown to exert promising anti-cancer effects. However, the underlying mechanisms remain elusive.

[Effect of traditional Chinese medicine in inhibiting obesity and inflammatory diseases by regulating gut microbiota].

Traditional Chinese medicine(TCM) has been increasingly used in the prevention and treatment of obesity and obesity-related diseases. However, its mechanism of action is not yet clear. In recent years, with the development of high-throughput sequencing technology, scientific researches have found that the disorder of gut microbiota is associated with obesity and other diseases.

Molecular epidemiology of in two tertiary care hospitals in Shandong Province, China.

Purpose: The incidence and severity of infection (CDI) have markedly increased over the past decade. However, there is very limited epidemiological data on CDI in China so far, specifically no data in Shandong Province. The aim of this study was to evaluate diagnostic algorithm for CDI and to gain data on molecular epidemiology of CDI in the Shandong Province of China.

CTG-loaded liposomes as an approach for improving the intestinal absorption of asiaticoside in Centella Total Glucosides.

Centella Total Glucosides (CTG),obtained from Centella asiatica (L.), have been shown to possess a multitude of pharmacological activities, however, oral administeration of CTG failed to fulfill their therapeutic potentials due to the low bioavailability. In this study, the author prepared the liposomes encapsulated CTG using the ethanol injection method in order to enhance their intestinal absorption.

[Effects of lycium on liver cellular ultrastructure and antioxidant activity of rats under tolerance training].

64 eight-week-old female rats were randomly divided into to 8 groups with four in medical treatment group and four in control group. The treatment groups were trained by progressive intensifying endurance swimming, and the medical-taken groups were fed with lycium for 5 weeks, and then the changes of the liver cellular free radical metabolism and ultrastructure were investigated. The effects of lycium and endurance training on liver cellular ultrastructure and free radical metabolism in rats were then explored.