Publications by authors named "Chenghe Ding"
Article Synopsis
- - Lactate is recognized as a key signaling molecule, and lactylation, a new type of modification that comes from lactate, significantly impacts various cellular processes like inflammation, development, tumor growth, and metabolism.
- - The exact ways in which lactylation affects these biological functions are not yet fully understood, highlighting the need for a detailed overview of this modification to clarify its relevance in health and disease.
- - This review summarizes the lactylation process, its role in different organisms, regulatory mechanisms in cellular functions, and identifies gaps in current research to suggest future study directions.
Background/objectives: Previous research has shown maternal betaine supplementation alleviates fetal-derived hepatic steatosis. Therefore, this study examined the anti-inflammatory effect of maternal betaine intake in offspring mice and its mechanism.
Materials/methods: Female C57BL/6J mice and their offspring were randomly divided into 3 groups according to the treatment received during gestation and lactation: control diet (CD), fatty liver disease (FLD), and fatty liver disease + 1% betaine (FLD-BET).
Radiotherapy remains an effective conventional method of treatment for patients with cancer. However, the clinical efficacy of radiotherapy is compromised by the development of radioresistance of the tumor cells during the treatment. Consequently, there is need for a comprehensive understanding of the regulatory mechanisms of tumor cells in response to radiation to improve radiotherapy efficacy.
View Article and Find Full Text PDFObjective: Clinical relevance of global DNA methylation and one-carbon metabolite levels with histological severity remains uncertain in patients with nonalcoholic fatty liver disease (NAFLD). This study aimed to evaluate hepatic global DNA methylation and serum one-carbon metabolite concentrations in patients with NAFLD and the possible associations of these parameters with liver histology.
Methods: Liver biopsies from 18 control participants and 47 patients with NAFLD were evaluated.
β-Carotene has been reported to alleviate hepatic steatosis (SS), inflammation, and fibrosis in vivo and vitro studies. However, the clinical relevance of serum β-carotene and β-carotene-to-retinol (SC/SR) ratio with histological severity in nonalcoholic fatty liver disease (NAFLD) patients is unknown. This case-control study enrolled 24 control subjects and 62 NAFLD patients.
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