Publications by authors named "Chenghao Wei"
Objective: To investigate the causal relationship between 91 circulating inflammatory proteins and Various asthma phenotypes by means of Mendelian randomization.
Methods: Genome-wide association Studies (GWAS) of 91 inflammatory proteins were pooled from the Olink Target platform with 14,824 participants. Various asthma phenotypes were derived from the FinnGen Biobank.
Purpose: This prospective study aimed to investigate estrogen-induced carcinogenesis by assessing the background levels of abasic sites (apurinic/apyrimidinic sites, AP sites) in Taiwanese breast cancer patients following 5 years of postoperative treatment without recurrence (5-year survivors) (n = 70). The study also sought to compare the extent of these DNA lesions with those found in healthy controls and in breast cancer patients prior to treatment.
Methods: Abasic sites were measured using an aldehyde reactive probe and quantified as the total number of abasic sites per total nucleotides.
Article Synopsis
- * Results revealed that HO induces primarily 5'- and 3'-nicked AP sites, whereas MMS creates mainly non-excisable, residual, and intact AP sites in the DNA samples analyzed.
- * Comparisons showed that AP site patterns in breast cancer patients before treatment were linked to DNA damage from reactive oxygen species, and 5-year survivors displayed similar site characteristics to healthy controls, indicating potential DNA repair deficiencies in the cancer patients.
Article Synopsis
- Rice-duck (RD) farming is an ecological method used in Asia to enhance rice production, but its long-term effects on rice growth are not fully understood.
- In experiments comparing various RD farming scales, it was found that RD farming led to reduced rice growth metrics (like tillers and yield), but improved factors such as root oxidation activity and yield stability.
- The study highlights the need to evaluate both the growth effects and economic benefits of RD farming at different scales for a comprehensive understanding of its impact on rice cultivation.