CPIExtract: A software package to collect and harmonize small molecule and protein interactions.

The binding interactions between small molecules and proteins are the basis of cellular functions. Yet, experimental data available regarding compound-protein interaction is not harmonized into a single entity but rather scattered across multiple institutions, each maintaining databases with different formats. Extracting information from these multiple sources remains challenging due to data heterogeneity.

Self-healing hydrogel with multiple adhesion as sensors for winter sports.

Hydrogels are widely used as sensors in the field of wearable devices. However, the hydrogels were rarely designed to endure the harsh outdoor environment in winter, including extremely low temperature, ultraviolet (UV) radiation and variable humidity. In addition, physical damage is also a challenge for hydrogels.

Sophocarpine inhibits tumor progression by antagonizing the PI3K/AKT/mTOR signaling pathway in castration-resistant prostate cancer.

Objective: The objective of this study was to investigate the inhibitory effect of sophocarpine on the progression of castration-resistant prostate cancer (CRPC) and the underlying molecular mechanism.

Methods: DU145 and PC3 cells (two CRPC cell lines), incubated with different concentrations of sophocarpine, were used. Cell Counting Kit-8 assay, real-time cellular analysis, and colony formation assay were conducted to evaluate the proliferation of CRPC cells.

Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling.

Pancreatic cancer is an extremely malignant digestive tract tumor. With the increase of chemotherapeutic resistance of pancreatic cancer, clinical treatment is in a dilemma. Hence, it is pivotal to design an effective drug for treating individuals with pancreatic cancer.

Management through Combined Use of Beneficial Insects and Thiacloprid in Pepper Seedlings.

insecticide application has posed a threat to pollinators and has also increased insecticide resistance of Sulzer. Therefore, it is urgent to develop an economical and effective strategy, especially for greenhouse vegetables. Firstly, we selected a neonicotinoid insecticide that is specifically fatal to but relatively safe to predators and bumblebees by laboratory toxicity tests and risk assessments.

[Phosphate Removal Using Rice Husk Biochars Modified with Lanthanum Hydroxide].

La-modified RHBCs (La-RHBCs) were fabricated by immobilizing La(OH) nanoparticles on mesoporous rice husk biochars (RHBCs) using a co-precipitation method. Specifically, the effects of the pore structure of the RHBCs, solution pH, and coexisting substances on phosphate adsorption by the La-RHBCs were studied. The results showed that the La loading of the La-RHBCs was positively correlated with the mesoporosity of the RHBCs.

Preferable phosphate removal by nano-La(III) hydroxides modified mesoporous rice husk biochars: Role of the host pore structure and point of zero charge.

Immobilizing La(OH) nanoparticles (NPs) to porous hosts has been widely applied to inhibiting their inherent aggregation as well as the subsequent low utilization efficiency of La. In this study, a series of rice husk biochars (RHBCs) with high mesoporous rates were prepared and the effects of host pore structure and point of zero charge (pH) on phosphate adsorption by La-modified RHBCs was particularly focused. Characterization results confirmed that La(OH) NPs were both confined in the pore channel and external surface of RHBCs.

Experimental demonstration of photonic entanglement collapse and revival.

We demonstrate the collapse and revival features of the entanglement dynamics of different polarization-entangled photon states in a non-Markovian environment. Using an all-optical experimental setup, we show that entanglement can be revived even after it suffers from sudden death. A maximally revived state is shown to violate a Bell's inequality with 4.

Experimental characterization of entanglement dynamics in noisy channels.

We experimentally characterize the bipartite entanglement under one-sided open system dynamics and verify the recently formulated entanglement factorization law [Nature Phys. 4, 99 (2008)]. The one-sided open system dynamics is realized by implementing a phase damping and an amplitude decay channel, respectively, acting on one of the qubits, by an all-optical setup.